Current and emerging therapies for corneal neovascularization
The cornea is unique because of its complete avascularity. Corneal neovascularization
(CNV) can result from a variety of etiologies including contact lens wear; corneal infections; …
(CNV) can result from a variety of etiologies including contact lens wear; corneal infections; …
Current and upcoming therapies for ocular surface chemical injuries
Chemical injuries frequently result in vision loss, disfigurement, and challenging ocular
surface complications. Acute interventions are directed at decreasing the extent of the injury …
surface complications. Acute interventions are directed at decreasing the extent of the injury …
Subconjunctival injectable dendrimer-dexamethasone gel for the treatment of corneal inflammation
Corneal inflammation is often encountered as a key pathological event in many corneal
diseases. Current treatments involve topical corticosteroids which require frequent …
diseases. Current treatments involve topical corticosteroids which require frequent …
[HTML][HTML] Up-to-date molecular medicine strategies for management of ocular surface neovascularization
Ocular surface neovascularization and its resulting pathological changes significantly alter
corneal refraction and obstruct light path to the retina, and hence is a major cause of vision …
corneal refraction and obstruct light path to the retina, and hence is a major cause of vision …
[HTML][HTML] Drp1-dependent mitochondrial fission mediates corneal injury induced by alkali burn
K Zhang, MY Guo, QG Li, XH Wang, YY Wan… - Free Radical Biology …, 2021 - Elsevier
Corneal alkali burn, one of the most serious ophthalmic emergencies, is difficult to be cured
by conservative treatments. It is well known that oxidative stress, inflammation and …
by conservative treatments. It is well known that oxidative stress, inflammation and …
Comprehensive modeling of corneal alkali injury in the rat eye
Purpose: To characterize the molecular, clinical, and histopathological profiles in the rat
cornea after alkali injury over a 21-day period. Methods: Alkali injury was induced in one eye …
cornea after alkali injury over a 21-day period. Methods: Alkali injury was induced in one eye …
Research models of sulfur mustard-and nitrogen mustard-induced ocular injuries and potential therapeutics
N Mishra, R Agarwal - Experimental eye research, 2022 - Elsevier
Sulfur mustard (SM) is a notorious, bifunctional alkylating vesicant that was first used in
warfare during World War I in 1917 and since then has been deployed in numerous …
warfare during World War I in 1917 and since then has been deployed in numerous …
[HTML][HTML] Therapeutic effects of an anti-IL-6 antibody in fungal keratitis: Macrophage inhibition and T cell subset regulation
L Peng, J Zhong, Y **ao, B Wang, S Li, Y Deng… - International …, 2020 - Elsevier
Immune modulation plays a critical role in the pathogenesis of fungal keratitis (FK).
However, the immune cell-mediated processes linking the innate immune response to the …
However, the immune cell-mediated processes linking the innate immune response to the …
Propagation of limbal stem cells on polycaprolactone and polycaprolactone/gelatin fibrous scaffolds and transplantation in animal model
Introduction: This study was conducted to compare the effect of nanofibrous
polycaprolactone (PCL) and PCL/gelatin (PCL/Gel) on limbal epithelial stem cell (LESC) …
polycaprolactone (PCL) and PCL/gelatin (PCL/Gel) on limbal epithelial stem cell (LESC) …
Differential expression of corneal and limbal cytokines and chemokines throughout the clinical course of sulfur mustard induced ocular injury in the rabbit model
V Horwitz, S Dachir, M Cohen, H Gutman… - Experimental Eye …, 2018 - Elsevier
Purpose The sight threatening sulfur mustard (SM) induced ocular injury presents specific
symptoms for each clinical stage. The acute injury develops in all of the exposed eyes and is …
symptoms for each clinical stage. The acute injury develops in all of the exposed eyes and is …