Traumatic brain injury (TBI) is a heterogeneous disorder that involves brain damage due to
external forces. TBI is the main factor of death and morbidity in young males with a high …

Background Delirium is the most common neuropsychiatric syndrome encountered by
clinicians dealing with older adults and the medically ill and is best characterized by 5 core …

Traumatic brain injury (TBI) is a significant clinical problem with few therapeutic interventions
successfully translated to the clinic. Increased importance on the progressive, long-term …

Delirium is a neurobehavioral syndrome caused by dysregulation of neuronal activity
secondary to systemic disturbances. Over time, a number of theories have been proposed in …

Background Newborn animal studies and pilot studies in humans suggest that mild
hypothermia following peripartum hypoxia‐ischaemia in newborn infants may reduce …

Background: Mild to moderate hypothermia (32–35 C) is the first treatment with proven
efficacy for postischemic neurological injury. In recent years important insights have been …

Current knowledge regarding the pathophysiology of cerebral ischemia and brain trauma
indicates that similar mechanisms contribute to loss of cellular integrity and tissue …

Glutamate excitotoxicity plays an important role in the development of secondary injuries
that occur following traumatic brain injury (TBI), and contributes significantly to expansion of …

Free radical-induced oxidative damage reactions, and membrane lipid peroxidation (LP), in
particular, are among the best validated secondary injury mechanisms in preclinical …

Delirium is the most common complication found in the general hospital setting. Yet, we
know relatively little about its actual pathophysiology. This article contains a summary of …