Improving protein stability is an important goal for basic research as well as for clinical and
industrial applications but no commonly accepted and widely used strategy for efficient …

Single-cell RNA sequencing is at the forefront of high-resolution phenoty** experiments
for complex samples. Although this methodology requires specialized equipment and …

Emerging methods for the accurate quantification of gene expression in individual cells hold
promise for revealing the extent, function and origins of cell-to-cell variability. Different high …

To understand the system of secreted proteins and receptors involved in cell-cell signaling,
we produced a comprehensive set of recombinant secreted proteins and the extracellular …

Trehalose, a naturally occurring osmolyte, is known to be an exceptional stabilizer of
proteins and helps retain the activity of enzymes in solution as well as in the freeze-dried …

Abstract The RIKEN Mouse Gene Encyclopaedia Project, a systematic approach to
determining the full coding potential of the mouse genome, involves collection and …

Microalgae are emerging as suitable feedstocks for renewable biofuel production.
Characterizing the metabolic pathways involved in the biosynthesis of energy-rich …

Genome-wide single-cell analysis represents the ultimate frontier of genomics research. In
particular, single-cell RNA-sequencing (scRNA-seq) studies have been boosted in the last …

Full-length complementary DNAs (cDNAs) are essential for the correct annotation of
genomic sequences and for the functional analysis of genes and their products. We isolated …

Dysfunction of autophagy, which regulates cellular homeostasis by degrading organelles
and proteins, is associated with pathogenesis of various diseases such as cancer …