New opportunities and old challenges in the clinical translation of nanotheranostics

PJ Gawne, M Ferreira, M Papaluca, J Grimm… - Nature Reviews …, 2023 - nature.com
Nanoparticle-based systems imbued with both diagnostic and therapeutic functions, known
as nanotheranostics, have enabled remarkable progress in guiding focal therapy, inducing …

Solutions to the drawbacks of photothermal and photodynamic cancer therapy

X Deng, Z Shao, Y Zhao - Advanced science, 2021 - Wiley Online Library
Phototherapy such as photothermal therapy and photodynamic therapy in cancer treatment
has been developed quickly over the past few years for its noninvasive nature and high …

Free radical as a double-edged sword in disease: Deriving strategic opportunities for nanotherapeutics

L Zhu, M Luo, Y Zhang, F Fang, M Li, F An… - Coordination chemistry …, 2023 - Elsevier
Free radicals, usually containing one or more unpaired electrons, are extremely unstable
and highly reactive with other biological molecules. Recently, there has been increasing …

Radiolabelling of nanomaterials for medical imaging and therapy

J Pellico, PJ Gawne, RTM de Rosales - Chemical Society Reviews, 2021 - pubs.rsc.org
Nanomaterials offer unique physical, chemical and biological properties of interest for
medical imaging and therapy. Over the last two decades, there has been an increasing effort …

Open‐shell nanosensitizers for glutathione responsive cancer sonodynamic therapy

H Wang, J Guo, W Lin, Z Fu, X Ji, B Yu, M Lu… - Advanced …, 2022 - Wiley Online Library
Deleterious effects to normal tissues and short biological half‐life of sonosensitizers limit the
applications of sonodynamic therapy (SDT). Herein, a new sonosensitizer (Cu (II) NS) is …

Critical learning from industrial catalysis for nanocatalytic medicine

Z **, L Jiang, Q He - Nature Communications, 2024 - nature.com
Systematical and critical learning from industrial catalysis will bring inspiration for emerging
nanocatalytic medicine, but the relevant knowledge is quite limited so far. In this review, we …

Transforming nuclear medicine with nanoradiopharmaceuticals

I Roy, S Krishnan, AV Kabashin, IN Zavestovskaya… - ACS …, 2022 - ACS Publications
Nuclear medicine is expected to make major advances in cancer diagnosis and therapy;
tumor-targeted radiopharmaceuticals preferentially eradicate tumors while causing minimal …

Single cell imaging of electrochemiluminescence‐driven photodynamic therapy

MM Chen, CH Xu, W Zhao, HY Chen… - Angewandte Chemie …, 2022 - Wiley Online Library
We report a photodynamic therapy driven by electrochemiluminescence (ECL). The
luminescence generated by Ru (bpy) 32+ and co‐reactant tripropylamine (TPA) pair acts as …

Beyond external light: on-spot light generation or light delivery for highly penetrated photodynamic therapy

X Cui, X Li, C Peng, Y Qiu, Y Shi, Y Liu, JF Fei - Acs Nano, 2023 - ACS Publications
External light sources, such as lasers, light emitting diodes (LEDs) and lamps, are widely
applied in photodynamic therapy (PDT); however, their use is severely limited by the nature …

A Radioluminescent Metal–Organic Framework for Monitoring 225Ac in Vivo

Y Zhang, F Li, Z Cui, K Li, J Guan, L Tian… - Journal of the …, 2023 - ACS Publications
225Ac is considered as one of the most promising radioisotopes for alpha-therapy because
its emitted high-energy α-particles can efficiently damage tumor cells. However, it also …