Meta-analysis of metabolites involved in bioenergetic pathways reveals a pseudohypoxic state in Down syndrome
Clinical observations and preclinical studies both suggest that Down syndrome (DS) may be
associated with significant metabolic and bioenergetic alterations. However, the relevant …
associated with significant metabolic and bioenergetic alterations. However, the relevant …
Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain
Pain is a common non-motor symptom of Parkinson's disease (PD), with current limited
knowledge of its pathophysiology. Here, we show that peripheral inoculation of mouse alpha …
knowledge of its pathophysiology. Here, we show that peripheral inoculation of mouse alpha …
[HTML][HTML] Virtual Reality-Based Therapy Can Enhance Balance and Muscular Endurance in Children and Adolescents with Down Syndrome: A Systematic Review with …
Physical exercises are crucial for enhancing postural balance and muscle strength in
children and adolescents with Down syndrome (DS). Virtual reality-based therapy (VRBT) …
children and adolescents with Down syndrome (DS). Virtual reality-based therapy (VRBT) …
Peripheral Nerve Regeneration Is Independent From Schwann Cell p75NTR Expression
NP Gonçalves, S Mohseni, M El Soury… - Frontiers in cellular …, 2019 - frontiersin.org
Schwann cell reprogramming and differentiation are crucial prerequisites for neuronal
regeneration and re-myelination to occur following injury to peripheral nerves. The …
regeneration and re-myelination to occur following injury to peripheral nerves. The …
Sarcopenia-related parameters in adults with Down syndrome: a cross-sectional exploratory study
Abstract Background People with Down syndrome (DS) experience premature aging.
Whether this accelerated aging also involves early declines in muscle mass, strength and …
Whether this accelerated aging also involves early declines in muscle mass, strength and …
Body composition parameters and sarcopenia in adults with Down syndrome: a case–control study
Abstract Background Individuals with Down syndrome (DS) experience premature aging.
Whether accelerated aging involves changes in body composition parameters and is …
Whether accelerated aging involves changes in body composition parameters and is …
Schwann cell p75 neurotrophin receptor modulates small fiber degeneration in diabetic neuropathy
NP Gonçalves, SE Jager, M Richner, SS Murray… - Glia, 2020 - Wiley Online Library
Diabetic neuropathy has an incidence as high as 50% of diabetic patients and is
characterized by damage to neurons, Schwann cells and blood vessels within the peripheral …
characterized by damage to neurons, Schwann cells and blood vessels within the peripheral …
Down syndrome: orofacial pain, masticatory muscle hypotonia, and sleep disorders
B Dicieri-Pereira, MF Gomes, LC Giannasi, SR Nacif… - Sleep, 2022 - academic.oup.com
The aim of the present study was to investigate orofacial pain in individuals with Down
syndrome (DS) and determine possible associations with masticatory muscle hypotonia …
syndrome (DS) and determine possible associations with masticatory muscle hypotonia …
Evaluation of the masticatory biomechanical function in Down syndrome and its Influence on sleep disorders, body adiposity and salivary parameters
MF Gomes, LC Giannasi… - Journal of Oral …, 2020 - Wiley Online Library
Objective To evaluate the phenotypic features of the masticatory biomechanics in atypical
subjects with Down syndrome (DS). Its influence was analysed on sleep disorders, body …
subjects with Down syndrome (DS). Its influence was analysed on sleep disorders, body …
Predictors of the Social Participation of Adults with Down Syndrome: An Analysis Based on the Biopsychosocial Model of the International Classification of Functioning …
Objective The aim of the study is to identify the predictors of social participation in Down
syndrome adults from the biopsychosocial model of the International Classification of …
syndrome adults from the biopsychosocial model of the International Classification of …