Our ancestors acquired morphological, cognitive and metabolic modifications that enabled
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …

Hybridization is an evolutionary phenomenon that has fascinated biologists for centuries.
Prior to the advent of whole-genome sequencing, it was clear that hybridization had played …

The vast majority of missense variants observed in the human genome are of unknown
clinical significance. We present AlphaMissense, an adaptation of AlphaFold fine-tuned on …

The rich diversity of morphology and behavior displayed across primate species provides an
informative context in which to study the impact of genomic diversity on fundamental …

Personalized genome sequencing has revealed millions of genetic differences between
individuals, but our understanding of their clinical relevance remains largely incomplete. To …

Motivation fastsimcoal2 extends fastsimcoal, a continuous time coalescent-based genetic
simulation program, by enabling the estimation of demographic parameters under very …

The completion of a telomere-to-telomere human reference genome, T2T-CHM13, has
resolved complex regions of the genome, including repetitive and homologous regions …

Neanderthals and Denisovans are extinct groups of hominins that separated from each
other more than 390,000 years ago,. Here we present the genome of 'Denisova 11', a bone …

Abstract “Conservation genomics” encompasses the idea that genome-scale data will
improve the capacity of resource managers to protect species. Although genetic approaches …

The Pacific region is of major importance for addressing questions regarding human
dispersals, interactions with archaic hominins and natural selection processes. However, the …