Natural products (NPs) have long been used as a rich source of bioactive compounds for
drug development. Recent technological advancements have revitalised natural products …

Vascular smooth muscle cell (vSMC) dysfunction is a critical contributor to cardiovascular
diseases, including atherosclerosis, restenosis and vein graft failure. Recent advances have …

Abstract Background and Purpose Our previous studies have found that andrographolide
(AGP) alleviates calcific aortic valve disease (CAVD), but the underlying mechanism is …

Abstract Background and Purpose Doxorubicin is widely used in the treatment of malignant
tumours, but doxorubicin‐induced cardiotoxicity severely limits its clinical application …

More than 30 years after their discovery, arrestins are recognised multiprotein scaffolds that
play essential roles in G protein‐coupled receptor (GPCR) regulation and signalling …

Abstract Background and Purpose White adipose tissue (WAT) is involved in rheumatoid
arthritis (RA). This study explored its potential as an antirheumatic target. Experimental …

Abstract Background and Purpose MicroRNA (miR)‐210 function in endothelial cells and its
role in diabetes‐associated endothelial dysfunction are not fully understood. We aimed to …

Abstract Background and Purpose Nicorandil, a selective opener of potassium channels,
used to treat angina, has drawn attention for its potential in mitigating lung injury, positioning …

Cardio‐cerebrovascular diseases encompass pathological changes in the heart, brain and
vascular system, which pose a great threat to health and well‐being worldwide. Moreover …

Background and Purpose The PDE4 family is considered a prime target for therapeutic
intervention in several fibro‐inflammatory diseases. We have investigated the molecular …