The roles of MicroRNAs in cadmium toxicity and in the protection offered by plant food-derived dietary phenolic bioactive substances against cadmium-induced toxicity

R Hao, F Li, D Sun-Waterhouse, D Li - Food Chemistry, 2024 - Elsevier
Cadmium, a harmful food contaminant, poses severe health risks. There are ongoing efforts
to reduce cadmium pollution and alleviate its toxicity, including plant-based dietary …

Carvacrol reduces mercuric chloride-induced testicular toxicity by regulating oxidative stress, inflammation, apoptosis, autophagy, and histopathological changes

H Şimşek, C Gür, S Küçükler, M İleritürk… - … Trace Element Research, 2024 - Springer
Mercuric chloride (HgCl2) is a heavy metal that is toxic to the human body. Carvacrol (CAR)
is a flavonoid found naturally in plants and has many biological and pharmacological …

Effect of syringic acid on oxidative stress, autophagy, apoptosis, inflammation pathways against testicular damage induced by lead acetate.

SA Akarsu, C Gür, M İleritürk, N Akaras… - Journal of Trace …, 2023 - Elsevier
Background Heavy metals are one of the environmental pollutants. Lead (Pb) is one of the
most common of these heavy metals. In this study, it was aimed at investigating the effects of …

The ameliorative effect of carvacrol on sodium arsenite‐induced hepatotoxicity in rats: Possible role of Nrf2/HO‐1, RAGE/NLRP3, Bax/Bcl‐2/Caspase‐3, and Beclin‐1 …

S Gencer, C Gür, M İleritürk, S Küçükler… - … of biochemical and …, 2024 - Wiley Online Library
Arsenic is a toxic environmental pollutant heavy metal, and one of its critical target tissues in
the body is the liver. Carvacrol is a natural phytocompound that stands out with its …

Amelioration effects and regulatory mechanisms of different tea active ingredients on DSS-Induced colitis

K Wei, Y Wei, Y Wang, X Wei - Journal of Agricultural and Food …, 2023 - ACS Publications
The potential biological function of tea and its active components on colitis has attracted
wide attention. In this study, different tea active ingredients including tea polyphenols …

Protective effects of sinapic acid against lead acetate-induced nephrotoxicity: a multi-biomarker approach

H Şimşek, S Küçükler, C Gür, N Akaras… - … Science and Pollution …, 2023 - Springer
Lead acetate (PbAc) is one of the top five most dangerous toxic heavy metals, particularly
leading to kidney damage and posing serious health risks in both humans and animals …

Chrysin attenuates paclitaxel-induced hepatorenal toxicity in rats by suppressing oxidative damage, inflammation, and apoptosis

S Çomaklı, S Özdemir, M Güloğlu - Life Sciences, 2023 - Elsevier
Abstract Aims Paclitaxel (Pax) is a chemotherapeutic drug from the taxane family that is used
in the treatment of human cancer, including ovarian, breast, and non-small cell lung …

[HTML][HTML] Protective effects of zingerone against sodium arsenite-induced lung toxicity: A multi-biomarker approach

H Şimşek, S Küçükler, C Gür, M İleritürk… - Iranian Journal of …, 2023 - ncbi.nlm.nih.gov
Objective (s): Sodium arsenite (SA) exposure is toxic to the body. Zingerone (ZNG) is a
flavonoid with many biological properties found naturally in honey and plants. This study …

Effects of chrysin in cadmium-induced testicular toxicity in the rat; role of multi-pathway regulation

SÇ Tuncer, S Küçükler, C Gür, S Aygörmez… - Molecular Biology …, 2023 - Springer
Abstract Background Cadmium (Cd) is a strong toxic agent and causes serious damage to
testicular tissues. Chrysin (CHR) is a natural flavonoid with many effective properties …

Ameliorative effects of sinapic acid against vancomycin-induced testicular oxidative damage, apoptosis, inflammation, testicular histopathologic disorders and …

SA Akarsu, M İleritürk, S Küçükler, N Akaras… - Reproductive …, 2024 - Elsevier
In this study, it was aimed to determine the effect of sinapic acid (SNP), a polyphenol with
antioxidant, anti-inflammatory and antibacterial properties, on testicular damage caused by …