Primary cilia project from the surface of most vertebrate cells and are key in sensing
extracellular signals and locally transducing this information into a cellular response. Recent …

Chemical synapses between axons and dendrites mediate neuronal intercellular
communication. Here, we describe a synapse between axons and primary cilia: the axo …

Many neurodegenerative diseases have been associated with defects in primary cilia, which
are cellular organelles involved in diverse cellular processes and homeostasis. Several …

The primary cilium is a dynamic subcellular compartment templated from the mother
centriole or basal body. Cilia are solitary and tiny, but remarkably consequential in cellular …

Primary cilia are sensory membrane protrusions whose dysfunction causes ciliopathies.
INPP5E is a ciliary phosphoinositide phosphatase mutated in ciliopathies like Joubert …

Arl13b, an ARF/Arl-family GTPase, is highly enriched in the cilium. Recent studies have
established Arl13b as one of the most crucial regulators for ciliary organization, trafficking …

The intraflagellar transport (IFT) machinery mediates the import and export of ciliary proteins
across the ciliary gate, as well as bidirectional protein trafficking within cilia. In addition to …

Abstract The serotonin 5-HT 6 receptor (5-HT 6 R) is a promising target to improve cognitive
symptoms of psychiatric diseases of neurodevelopmental origin, such as autism spectrum …

Primary cilia are hair-like projections of the cell membrane supported by an inner
microtubule scaffold, the axoneme, which polymerizes out of a membrane-docked centriole …

Opioid receptors are therapeutically important G protein-coupled receptors (GPCRs) with
diverse neuromodulatory effects. The functional consequences of opioid receptor activation …