Modern medical management of spinal cord injury

M Karsy, G Hawryluk - Current Neurology and Neuroscience Reports, 2019 - Springer
Abstract Purpose of Review Spinal cord injury (SCI) shows an incidence of 10.4–83
cases/million/year globally and remains a significant source of morbidity and cost to society …

Regeneration of spinal cord connectivity through stem cell transplantation and biomaterial scaffolds

H Katoh, K Yokota, MG Fehlings - Frontiers in cellular neuroscience, 2019 - frontiersin.org
Significant progress has been made in the treatment of spinal cord injury (SCI). Advances in
post-trauma management and intensive rehabilitation have significantly improved the …

The influence of timing of surgical decompression for acute spinal cord injury: a pooled analysis of individual patient data

JH Badhiwala, JR Wilson, CD Witiw, JS Harrop… - The Lancet …, 2021 - thelancet.com
Background Although there is a strong biological rationale for early decompression of the
injured spinal cord, the influence of the timing of surgical decompression for acute spinal …

Restoration of spinal cord biophysical microenvironment for enhancing tissue repair by injury-responsive smart hydrogel

C Fan, W Yang, L Zhang, H Cai, Y Zhuang, Y Chen… - Biomaterials, 2022 - Elsevier
Spinal cord injury (SCI) represents a central nervous system disaster, resulting in the
destruction of spinal cord structure and function and the formation of an adverse …

Cell therapies for spinal cord injury: a review of the clinical trials and cell-type therapeutic potential

BF Ribeiro, BC da Cruz, BM de Sousa, PD Correia… - Brain, 2023 - academic.oup.com
Spinal cord injury (SCI) is an as yet untreatable neuropathology that causes severe
dysfunction and disability. Cell-based therapies hold neuroregenerative and neuroprotective …

The leading edge: Emerging neuroprotective and neuroregenerative cell-based therapies for spinal cord injury

CS Ahuja, A Mothe, M Khazaei… - Stem cells …, 2020 - academic.oup.com
Spinal cord injuries (SCIs) are associated with tremendous physical, social, and financial
costs for millions of individuals and families worldwide. Rapid delivery of specialized …

[HTML][HTML] Clinical trials of stem cell treatment for spinal cord injury

K Yamazaki, M Kawabori, T Seki, K Houkin - International Journal of …, 2020 - mdpi.com
There are more than one million patients worldwide suffering paralysis caused by spinal
cord injury (SCI). SCI causes severe socioeconomic problems not only to the patients and …

Synergistic pharmacological therapy to modulate glial cells in spinal cord injury

V Veneruso, E Petillo, F Pizzetti, A Orro… - Advanced …, 2024 - Wiley Online Library
Current treatments for modulating the glial‐mediated inflammatory response after spinal
cord injury (SCI) have limited ability to improve recovery. This is quite likely due to the lack of …

Neuroimmunological therapies for treating spinal cord injury: Evidence and future perspectives

JCT Chio, KJ Xu, P Popovich, S David… - Experimental neurology, 2021 - Elsevier
Spinal cord injury (SCI) has a complex pathophysiology. Following the initial physical
trauma to the spinal cord, which may cause vascular disruption, hemorrhage, mechanical …

Regenerative rehabilitation with conductive biomaterials for spinal cord injury

EA Kiyotake, MD Martin, MS Detamore - Acta biomaterialia, 2022 - Elsevier
The individual approaches of regenerative medicine efforts alone and rehabilitation efforts
alone have not yet fully restored function after severe spinal cord injury (SCI). Regenerative …