There is a large global unmet need for the development of countermeasures to combat
hundreds of viruses known to cause human disease and for the establishment of a …

Japanese encephalitis virus (JEV) is a flavivirus, spread by the bite of carrier Culex
mosquitoes. The subsequent disease caused is Japanese encephalitis (JE), which is the …

Historically, emerging viruses appear constantly and have cost millions of human lives.
Currently, climate change and intense globalization have created favorable conditions for …

Japanese encephalitis virus (JEV) is the causal agent behind Japanese encephalitis (JE), a
potentially severe brain infection that spreads through mosquito bites. JE is predominant …

Viral genetic diversity presents significant challenges in develo** antivirals with broad-
spectrum activity and high barriers to resistance. Here we report development of proteolysis …

In the context of the only available vaccine (DENGVAXIA) that was marketed in several
countries, but poses higher risks to unexposed individuals, the development of antivirals for …

Dengue is an arthropod-borne viral disease that has become endemic and a global threat in
many countries with no effective antiviral drug available currently. This study showed that …

Flaviviruses are vector-borne pathogens capable of causing devastating human diseases.
The re-emergence of Zika in 2016 notoriously led to a widescale epidemic in the Americas …

Japanese encephalitis is a mosquito-borne disease caused by the Japanese encephalitis
virus (JEV) that is prevalent in Asia and the Western Pacific. Currently, there is no effective …

Flavone has recently been proved as a promising scaffold for the development of a novel
drug against dengue fever, one of the major health threats globally. However, the structure …