Overcoming cancer therapeutic bottleneck by drug repurposing
Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …
the development of the alternative strategy of drug repurposing, the development of old …
[HTML][HTML] Drug-induced oxidative stress in cancer treatments: Angel or devil?
H Jiang, J Zuo, B Li, R Chen, K Luo, X **ang, S Lu… - Redox Biology, 2023 - Elsevier
Oxidative stress (OS), defined as redox imbalance in favor of oxidant burden, is one of the
most significant biological events in cancer progression. Cancer cells generally represent a …
most significant biological events in cancer progression. Cancer cells generally represent a …
Anti-angiogenic therapy: current challenges and future perspectives
F Lopes-Coelho, F Martins, SA Pereira… - International journal of …, 2021 - mdpi.com
Anti-angiogenic therapy is an old method to fight cancer that aims to abolish the nutrient and
oxygen supply to the tumor cells through the decrease of the vascular network and the …
oxygen supply to the tumor cells through the decrease of the vascular network and the …
Mitophagy: molecular mechanisms, new concepts on parkin activation and the emerging role of AMPK/ULK1 axis
R Iorio, G Celenza, S Petricca - Cells, 2021 - mdpi.com
Mitochondria are multifunctional subcellular organelles essential for cellular energy
homeostasis and apoptotic cell death. It is, therefore, crucial to maintain mitochondrial …
homeostasis and apoptotic cell death. It is, therefore, crucial to maintain mitochondrial …
Avermectin derivatives, pharmacokinetics, therapeutic and toxic dosages, mechanism of action, and their biological effects
Avermectins are a group of drugs that occurs naturally as a product of fermenting
Streptomyces avermitilis, an actinomycetes, isolated from the soil. Eight different structures …
Streptomyces avermitilis, an actinomycetes, isolated from the soil. Eight different structures …
An aberrant STAT pathway is central to COVID-19
T Matsuyama, SP Kubli, SK Yoshinaga… - Cell Death & …, 2020 - nature.com
COVID-19 is caused by SARS-CoV-2 infection and characterized by diverse clinical
symptoms. Type I interferon (IFN-I) production is impaired and severe cases lead to ARDS …
symptoms. Type I interferon (IFN-I) production is impaired and severe cases lead to ARDS …
The mechanisms of action of ivermectin against SARS-CoV-2—an extensive review
Considering the urgency of the ongoing COVID-19 pandemic, detection of new mutant
strains and potential re-emergence of novel coronaviruses, repurposing of drugs such as …
strains and potential re-emergence of novel coronaviruses, repurposing of drugs such as …
[HTML][HTML] The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug
M Juarez, A Schcolnik-Cabrera… - American journal of …, 2018 - ncbi.nlm.nih.gov
Drug repositioning is a highly studied alternative strategy to discover and develop
anticancer drugs. This drug development approach identifies new indications for existing …
anticancer drugs. This drug development approach identifies new indications for existing …
Targeting tumor hypoxia and mitochondrial metabolism with anti-parasitic drugs to improve radiation response in high-grade gliomas
Abstract High-grade gliomas (HGGs), including glioblastoma and diffuse intrinsic pontine
glioma, are amongst the most fatal brain tumors. These tumors are associated with a dismal …
glioma, are amongst the most fatal brain tumors. These tumors are associated with a dismal …
[HTML][HTML] Berberine represses human gastric cancer cell growth in vitro and in vivo by inducing cytostatic autophagy via inhibition of MAPK/mTOR/p70S6K and Akt …
Berberine, an isoquinoline alkaloid from Coptidis Rhizoma, has been characterized as a
potential anticancer drug due to its good anti-tumor effects. However, the molecular …
potential anticancer drug due to its good anti-tumor effects. However, the molecular …