Emerging roles for the gut microbiome in autism spectrum disorder

HE Vuong, EY Hsiao - Biological psychiatry, 2017 - Elsevier
Autism spectrum disorder (ASD) is a serious neurodevelopmental disorder that affects one
in 45 children in the United States, with a similarly striking prevalence in countries around …

The rodent forced swim test measures stress-co** strategy, not depression-like behavior

KG Commons, AB Cholanians, JA Babb… - ACS chemical …, 2017 - ACS Publications
The forced swim test (FST) measures co** strategy to an acute inescapable stress and
thus provides unique insight into the neural limb of the stress response. Stress, particularly …

Autism spectrum disorder: focus on glutamatergic neurotransmission

M Montanari, G Martella, P Bonsi… - International Journal of …, 2022 - mdpi.com
Disturbances in the glutamatergic system have been increasingly documented in several
neuropsychiatric disorders, including autism spectrum disorder (ASD). Glutamate-centered …

Genetic and non-genetic animal models for autism spectrum disorders (ASD)

Z Ergaz, L Weinstein-Fudim, A Ornoy - Reproductive Toxicology, 2016 - Elsevier
Autism spectrum disorder (ASD) is associated, in addition to complex genetic factors, with a
variety of prenatal, perinatal and postnatal etiologies. We discuss the known animal models …

A subset of autism-associated genes regulate the structural stability of neurons

YC Lin, JA Frei, MBC Kilander, W Shen… - Frontiers in cellular …, 2016 - frontiersin.org
Autism spectrum disorder (ASD) comprises a range of neurological conditions that affect
individuals' ability to communicate and interact with others. People with ASD often exhibit …

Downregulation of kainate receptors regulating GABAergic transmission in amygdala after early life stress is associated with anxiety-like behavior in rodents

J Englund, J Haikonen, V Shteinikov… - Translational …, 2021 - nature.com
Early life stress (ELS) is a well-characterized risk factor for mood and anxiety disorders.
GABAergic microcircuits in the amygdala are critically implicated in anxiety; however …

Kainate receptors and synaptic plasticity

JD Nair, KA Wilkinson, JM Henley, JR Mellor - Neuropharmacology, 2021 - Elsevier
Synaptic plasticity has classically been characterized to involve the NMDA and AMPA
subtypes of glutamate receptors, with NMDA receptors providing the key trigger for the …

Emerging synaptic molecules as candidates in the etiology of neurological disorders

VI Torres, D Vallejo, NC Inestrosa - Neural plasticity, 2017 - Wiley Online Library
Synapses are complex structures that allow communication between neurons in the central
nervous system. Studies conducted in vertebrate and invertebrate models have contributed …

Brain Specific RagA Overexpression Triggers Depressive‐Like Behaviors in Mice via Activating ADORA2A Signaling Pathway

J Zhao, Y Sun, Y Feng, J Rong - Advanced Science, 2024 - Wiley Online Library
Neuroinflammation hallmarks the pathology of depression although the etiological
complexity has not yet been resolved. Previous studies demonstrate that bacterial …

Kainate receptors: from synaptic activity to disease

JV Negrete‐Díaz, R Falcón‐Moya… - The FEBS …, 2022 - Wiley Online Library
Kainate receptors (KARs) are glutamate receptors that participate in the postsynaptic
transmission of information and in the control of neuronal excitability, as well as …