Obesity and type 2 diabetes have both been associated with increased cancer risk and are
becoming increasingly prevalent. Metabolic abnormalities such as insulin resistance and …

The disorder of lipid metabolism is pathologically linked to hyperlipidemia, lipid storage
disease, obesity and other related diseases. Intriguingly, recent studies have revealed that …

Deregulated cell proliferation is an established feature of cancer, and altered tumor
metabolism has witnessed renewed interest over the past decade, including the study of …

Cholesterol is essential for cell function and viability. It is a component of the plasma
membrane and lipid rafts and is a precursor for bile acids, steroid hormones, and Vitamin D …

Oxysterols are cholesterol metabolites generated in the liver and other peripheral tissues as
a mechanism of removing excess cholesterol. Oxysterols have a wide range of biological …

The gut bacterial community is involved in the metabolism of bile acids and short‐chain fatty
acids (SCFAs). Bile acids are involved in the absorption of fat and the regulation of lipid …

Oxysterols are derivatives of cholesterol and an important regulator of cholesterol
metabolism, in part due to their role as ligands for nuclear receptors, such as the liver X …

Estrogen receptor β (ERβ) plays critical roles in thyroid cancer progression. However, its role
in thyroid cancer stem cell maintenance remains elusive. Here, we report that ERβ is …

Cholesterol has been implicated in the pathophysiology and progression of several cancers
now, although the mechanisms by which it influences cancer biology are just emerging. Two …

Hypercholesterolemia is a risk factor for neurodegenerative diseases, but how high blood
cholesterol levels are linked to neurodegeneration is still unknown. Here, we show that an …