Background Total knee arthroplasty (TKA) relieves pain and improves quality of life for
persons with advanced knee osteoarthritis. However, to our knowledge, the cost …

The use of decision-analytic modelling for the purpose of health technology assessment
(HTA) has increased dramatically in recent years. Several guidelines for best practice have …

Background Early recognition and management of postoperative complications, before they
become clinically relevant, can improve postoperative outcomes for patients, especially for …

The third volume in the Handbooks in Health Economic Evaluation series, this book
provides the reader with a comprehensive set of instructions and examples of how to …

READ ALL ABOUT IT! David Spiegelhalter has recently joined the ranks of Isaac Newton,
Charles Darwin and Stephen Hawking by becoming a fellow of the Royal Society …

ContextAlthough diabetes mellitus is one of the most prevalent and costly chronic diseases
in the United States, no estimates have been published of individuals' average lifetime risk …

Several guidelines on cost-effectiveness analysis (CEA) already exist. There are two
reasons for producing another set. The first is that traditional or, incremental, CEA ignores …

The objective of this study was to evaluate the effect of pharmacogenetics-guided treatment
on patients diagnosed with depression and/or anxiety, in a diverse set of clinical settings, as …

Background More than 90% of vision impairment is avoidable. However, in China, a routine
screening programme is currently unavailable in primary health care. With the dearth of …

Policy makers seeking to reduce childhood obesity must prioritize investment in treatment
and primary prevention. We estimated the cost-effectiveness of seven interventions high on …