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Control of lymphocyte functions by gut microbiota-derived short-chain fatty acids
A mounting body of evidence indicates that dietary fiber (DF) metabolites produced by
commensal bacteria play essential roles in balancing the immune system. DF, considered …
commensal bacteria play essential roles in balancing the immune system. DF, considered …
The function of Fcγ receptors in dendritic cells and macrophages
Dendritic cells (DCs) and macrophages use various receptors to recognize foreign antigens
and to receive feedback control from adaptive immune cells. Although it was long believed …
and to receive feedback control from adaptive immune cells. Although it was long believed …
Cross-tissue organization of the fibroblast lineage
Fibroblasts are non-haematopoietic structural cells that define the architecture of organs,
support the homeostasis of tissue-resident cells and have key roles in fibrosis, cancer …
support the homeostasis of tissue-resident cells and have key roles in fibrosis, cancer …
Low-dose radiotherapy reverses tumor immune desertification and resistance to immunotherapy
Develo** strategies to inflame tumors is critical for increasing response to immunotherapy.
Here, we report that low-dose radiotherapy (LDRT) of murine tumors promotes T-cell …
Here, we report that low-dose radiotherapy (LDRT) of murine tumors promotes T-cell …
A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate
Mitochondrial fatty acid oxidation (FAO) is essential for hematopoietic stem cell (HSC) self-
renewal; however, the mechanism by which mitochondrial metabolism controls HSC fate …
renewal; however, the mechanism by which mitochondrial metabolism controls HSC fate …
Poor repair of skeletal muscle in aging mice reflects a defect in local, interleukin-33-dependent accumulation of regulatory T cells
Normal repair of skeletal muscle requires local expansion of a special population of Foxp3+
CD4+ regulatory T (Treg) cells. Such cells failed to accumulate in acutely injured muscle of …
CD4+ regulatory T (Treg) cells. Such cells failed to accumulate in acutely injured muscle of …
Transcriptional atlas of intestinal immune cells reveals that neuropeptide α-CGRP modulates group 2 innate lymphoid cell responses
Signaling abnormalities in immune responses in the small intestine can trigger chronic type
2 inflammation involving interaction of multiple immune cell types. To systematically …
2 inflammation involving interaction of multiple immune cell types. To systematically …
Resident and circulating memory T cells persist for years in melanoma patients with durable responses to immunotherapy
While T-cell responses to cancer immunotherapy have been avidly studied, long-lived
memory has been poorly characterized. In a cohort of metastatic melanoma survivors with …
memory has been poorly characterized. In a cohort of metastatic melanoma survivors with …
A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model
Microglia are resident immune cells of the CNS that are activated by infection, neuronal
injury, and inflammation. Here, we utilize flow cytometry and deep RNA sequencing of …
injury, and inflammation. Here, we utilize flow cytometry and deep RNA sequencing of …
BloodSpot: a database of gene expression profiles and transcriptional programs for healthy and malignant haematopoiesis
Research on human and murine haematopoiesis has resulted in a vast number of gene-
expression data sets that can potentially answer questions regarding normal and aberrant …
expression data sets that can potentially answer questions regarding normal and aberrant …