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[HTML][HTML] Molecular and circulating biomarkers in patients with glioblastoma
Glioblastoma is the most aggressive malignant tumor of the central nervous system with a
low survival rate. The difficulty of obtaining this tumor material represents a major limitation …
low survival rate. The difficulty of obtaining this tumor material represents a major limitation …
Adult type diffuse gliomas in the new 2021 WHO Classification
Adult-type diffuse gliomas represent a group of highly infiltrative central nervous system
tumors with a prognosis that significantly varies depending on the specific subtype and …
tumors with a prognosis that significantly varies depending on the specific subtype and …
A combination of TERT promoter mutation and MGMT methylation status predicts clinically relevant subgroups of newly diagnosed glioblastomas
H Arita, K Yamasaki, Y Matsushita, T Nakamura… - Acta neuropathologica …, 2016 - Springer
The prognostic impact of TERT mutations has been controversial in IDH-wild tumors,
particularly in glioblastomas (GBM). The controversy may be attributable to presence of …
particularly in glioblastomas (GBM). The controversy may be attributable to presence of …
Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity
In contrast to the relative morphological uniformity of histone H3 K27-mutant high-grade
gliomas, H3 G34-mutant tumors present as a histopathologically heterogeneous group of …
gliomas, H3 G34-mutant tumors present as a histopathologically heterogeneous group of …
Effective reprogramming of patient-derived M2-polarized glioblastoma-associated microglia/macrophages by treatment with GW2580
Purpose: Targeting immunosuppressive and pro-tumorigenic glioblastoma (GBM)-
associated macrophages and microglial cells (GAM) has great potential to improve patient …
associated macrophages and microglial cells (GAM) has great potential to improve patient …
[HTML][HTML] Beyond IDH-mutation: emerging molecular diagnostic and prognostic features in adult diffuse gliomas
Diffuse gliomas are among the most common adult central nervous system tumors with an
annual incidence of more than 16,000 cases in the United States. Until very recently, the …
annual incidence of more than 16,000 cases in the United States. Until very recently, the …
Multidimensional scaling of diffuse gliomas: application to the 2016 World Health Organization classification system with prognostically relevant molecular subtype …
Recent updating of the World Health Organization (WHO) classification of central nervous
system (CNS) tumors in 2016 demonstrates the first organized effort to restructure brain …
system (CNS) tumors in 2016 demonstrates the first organized effort to restructure brain …
Metabolic-imaging of human glioblastoma live tumors: A new precision-medicine approach to predict tumor treatment response early
Background Glioblastoma (GB) is the most severe form of brain cancer, with a 12-15 month
median survival. Surgical resection, temozolomide (TMZ) treatment, and radiotherapy …
median survival. Surgical resection, temozolomide (TMZ) treatment, and radiotherapy …
Superiority of temozolomide over radiotherapy for elderly patients with RTK II methylation class, MGMT promoter methylated malignant astrocytoma
Background O6-methylguanine DNA-methyl transferase (MGMT) promoter methylation
status is predictive for alkylating chemotherapy, but there are non-benefiting subgroups …
status is predictive for alkylating chemotherapy, but there are non-benefiting subgroups …
Carbon irradiation overcomes glioma radioresistance by eradicating stem cells and forming an antiangiogenic and immunopermissive niche
S Chiblak, Z Tang, D Lemke, M Knoll, I Dokic… - JCI …, 2019 - pmc.ncbi.nlm.nih.gov
Tumor radioresistance leading to local therapy failure remains a major obstacle for
successful treatment of high-grade glioma. We hypothesized that distinct radiobiological …
successful treatment of high-grade glioma. We hypothesized that distinct radiobiological …