Mechanisms of DNA damage, repair, and mutagenesis
Living organisms are continuously exposed to a myriad of DNA damaging agents that can
impact health and modulate disease‐states. However, robust DNA repair and damage …
impact health and modulate disease‐states. However, robust DNA repair and damage …
Roles of RNA methylation by means of N6-methyladenosine (m6A) in human cancers
S Wang, C Sun, J Li, E Zhang, Z Ma, W Xu, H Li, M Qiu… - Cancer letters, 2017 - Elsevier
Reversible methylation by means of N6-methyladenosine (m 6 A) is the most prevalent
internal modification in mammalian mRNA. This RNA chemical mark is created by proteins …
internal modification in mammalian mRNA. This RNA chemical mark is created by proteins …
N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
We report here that fat mass and obesity-associated protein (FTO) has efficient oxidative
demethylation activity targeting the abundant N 6-methyladenosine (m6A) residues in RNA …
demethylation activity targeting the abundant N 6-methyladenosine (m6A) residues in RNA …
AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells
Y Ueda, I Ooshio, Y Fusamae, K Kitae, M Kawaguchi… - Scientific reports, 2017 - nature.com
The mammalian AlkB homolog (ALKBH) family of proteins possess a 2-oxoglutarate-and Fe
(II)-dependent oxygenase domain. A similar domain in the Escherichia coli AlkB protein …
(II)-dependent oxygenase domain. A similar domain in the Escherichia coli AlkB protein …
RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation
Y Yue, J Liu, C He - Genes & development, 2015 - genesdev.cshlp.org
N 6-methyladenosine (m6A) is the most prevalent and internal modification that occurs in the
messenger RNAs (mRNA) of most eukaryotes, although its functional relevance remained a …
messenger RNAs (mRNA) of most eukaryotes, although its functional relevance remained a …
Emerging roles of RNA modification: m6A and U-tail
M Lee, B Kim, VN Kim - Cell, 2014 - cell.com
Although more than 100 types of RNA modification have been described thus far, most of
them were thought to be rare in mRNAs and in regulatory noncoding RNAs. Recent …
them were thought to be rare in mRNAs and in regulatory noncoding RNAs. Recent …
Development of Cell-Active N6-Methyladenosine RNA Demethylase FTO Inhibitor
B Chen, F Ye, L Yu, G Jia, X Huang… - Journal of the …, 2012 - ACS Publications
The direct nucleic acid repair dioxygenase FTO is an enzyme that demethylates N 6-
methyladenosine (m6A) residues in mRNA in vitro and inside cells. FTO is the first RNA …
methyladenosine (m6A) residues in mRNA in vitro and inside cells. FTO is the first RNA …
Fe (II)/α-ketoglutarate-dependent hydroxylases and related enzymes
RP Hausinger - Critical reviews in biochemistry and molecular …, 2004 - Taylor & Francis
Fe (II)/α-ketoglutarate (αKG)-dependent hydroxylases catalyze an amazing diversity of
reactions that result in protein side-chain modifications, repair of alkylated DNA/RNA …
reactions that result in protein side-chain modifications, repair of alkylated DNA/RNA …
The pivotal regulatory landscape of RNA modifications
Posttranscriptionally modified nucleosides in RNA play integral roles in the cellular control of
biological information that is encoded in DNA. The modifications of RNA span all three …
biological information that is encoded in DNA. The modifications of RNA span all three …
Reversible RNA adenosine methylation in biological regulation
N 6-methyladenosine (m 6 A) is a ubiquitous modification in mRNA and other RNAs across
most eukaryotes. For many years, however, the exact functions of m 6 A were not clearly …
most eukaryotes. For many years, however, the exact functions of m 6 A were not clearly …