Biomarkers of neurodegeneration and neuronal injury have the potential to improve
diagnostic accuracy, disease monitoring, prognosis, and measure treatment efficacy …

Neuronal injury is a universal event that occurs in disease processes that affect both the
central and peripheral nervous systems. A blood biomarker linked to neuronal injury would …

Objective To determine the diagnostic and prognostic performance of serum neurofilament
light chain (NFL) in amyotrophic lateral sclerosis (ALS). Methods This single-centre …

Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease
and is characterized by the degeneration of upper and lower motor neurons. It has become …

Amyotrophic lateral sclerosis is a late-onset progressive neurodegenerative disease
affecting motor neurons. The etiology of most ALS cases remains unknown, but 2% of …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder
characterized by death of motor neurons leading to muscle wasting, paralysis, and death …

Mutations in the gene encoding TDP-43—the major protein component of neuronal
aggregates characteristic of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
progressive muscle paralysis determined by the degeneration of motoneurons in the motor …

Amyotrophic lateral sclerosis (ALS) is increasingly recognized to be a multisystem disorder
which includes both clinical and neuropathological features of a frontotemporal lobar …

There is a need for biomarkers for amyotrophic lateral sclerosis (ALS), to support the
diagnosis of the disease, to predict disease progression and to track disease activity and …