Mitochondrial protein transport: Versatility of translocases and mechanisms
JD Busch, LF Fielden, N Pfanner, N Wiedemann - Molecular Cell, 2023 - cell.com
Biogenesis of mitochondria requires the import of approximately 1,000 different precursor
proteins into and across the mitochondrial membranes. Mitochondria exhibit a wide variety …
proteins into and across the mitochondrial membranes. Mitochondria exhibit a wide variety …
Subcellular proteomics
The eukaryotic cell is compartmentalized into subcellular niches, including membrane-
bound and membrane-less organelles. Proteins localize to these niches to fulfil their …
bound and membrane-less organelles. Proteins localize to these niches to fulfil their …
[HTML][HTML] Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context
M Morgenstern, CD Peikert, P Lübbert, I Suppanz… - Cell metabolism, 2021 - cell.com
Mitochondria are key organelles for cellular energetics, metabolism, signaling, and quality
control and have been linked to various diseases. Different views exist on the composition of …
control and have been linked to various diseases. Different views exist on the composition of …
[HTML][HTML] An in vitro system to silence mitochondrial gene expression
LD Cruz-Zaragoza, S Dennerlein, A Linden, R Yousefi… - Cell, 2021 - cell.com
The human mitochondrial genome encodes thirteen core subunits of the oxidative
phosphorylation system, and defects in mitochondrial gene expression lead to severe …
phosphorylation system, and defects in mitochondrial gene expression lead to severe …
The multifaceted pyruvate metabolism: role of the mitochondrial pyruvate carrier
J Zangari, F Petrelli, B Maillot, JC Martinou - Biomolecules, 2020 - mdpi.com
Pyruvate, the end product of glycolysis, plays a major role in cell metabolism. Produced in
the cytosol, it is oxidized in the mitochondria where it fuels the citric acid cycle and boosts …
the cytosol, it is oxidized in the mitochondria where it fuels the citric acid cycle and boosts …
Structural basis of mitochondrial protein import by the TIM23 complex
Mitochondria import nearly all of their approximately 1,000–2,000 constituent proteins from
the cytosol across their double-membrane envelope,,,–. Genetic and biochemical studies …
the cytosol across their double-membrane envelope,,,–. Genetic and biochemical studies …
Structural insight into the SAM-mediated assembly of the mitochondrial TOM core complex
β barrel outer membrane proteins (β-OMPs) play vital roles in mitochondria, chloroplasts,
and Gram-negative bacteria. Evolutionarily conserved complexes such as the mitochondrial …
and Gram-negative bacteria. Evolutionarily conserved complexes such as the mitochondrial …
[HTML][HTML] Mitochondrial entry gate as regulatory hub
Mitochondria import 1000–1300 different precursor proteins from the cytosol. The main
mitochondrial entry gate is formed by the translocase of the outer membrane (TOM …
mitochondrial entry gate is formed by the translocase of the outer membrane (TOM …
[HTML][HTML] Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery
C Walter, A Marada, T Suhm, R Ernsberger… - Nature …, 2021 - nature.com
The translocase of the outer mitochondrial membrane TOM constitutes the organellar entry
gate for nearly all precursor proteins synthesized on cytosolic ribosomes. Thus, TOM …
gate for nearly all precursor proteins synthesized on cytosolic ribosomes. Thus, TOM …
Targeting and insertion of membrane proteins in mitochondria
R Eaglesfield, K Tokatlidis - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
Mitochondrial membrane proteins play an essential role in all major mitochondrial functions.
The respiratory complexes of the inner membrane are key for the generation of energy. The …
The respiratory complexes of the inner membrane are key for the generation of energy. The …