The most influential account of phasic dopamine holds that it reports reward prediction
errors (RPEs). The RPE-based interpretation of dopamine signaling is, in its original form …

One of the most exciting new developments in systems neuroscience is the progress being
made toward neurophysiological experiments that move beyond simplified laboratory …

Background Glucagon-like peptide1 receptor (GLP-1R) agonists have been found to reduce
alcohol drinking in rodents and overweight patients with alcohol use disorder (AUD) …

Chronic stress can have lasting adverse consequences in some individuals, yet others are
resilient to the same stressor,. Susceptible and resilient individuals exhibit differences in the …

Contemporary pose estimation methods enable precise measurements of behavior via
supervised deep learning with hand-labeled video frames. Although effective in many cases …

During goal-directed navigation,'what'information, describing the experiences occurring in
periods surrounding a reward, can be combined with spatial 'where'information to guide …

Notions of surprise and novelty have been used in various experimental and theoretical
studies across multiple brain areas and species. However,'surprise'and 'novelty'refer to …

Sensory feedback is integral for contextually appropriate motor output, yet the neural circuits
responsible remain elusive. Here, we pinpoint the medial deep dorsal horn of the mouse …

The hypothesis that midbrain dopamine (DA) neurons broadcast a reward prediction error
(RPE) is among the great successes of computational neuroscience. However, recent …

For many years, neuroscientists have investigated the behavioural, computational and
neurobiological mechanisms that support value-based decisions, revealing how humans …