Throughout history, natural products have played a dominant role in the treatment of human
ailments. For example, the legendary discovery of penicillin transformed global existence …

BACKGROUND: Nature has been a source of medicinal products for millennia, with many
useful drugs developed from plant sources. Following discovery of the penicillins, drug …

Cultivated bacteria such as actinomycetes are a highly useful source of biomedically
important natural products. However, such 'talented'producers represent only a minute …

There is a continuous need for iterative cycles of antibiotic discovery and development to
deal with the selection of resistant pathogens that emerge as therapeutic application of an …

Actinomycetes have been proven to be an excellent source of secondary metabolites for
more than half a century. Exhibiting various bioactivities, they provide valuable approved …

Chemical modification of enzymes and immobilization used to be considered as separate
ways to improve enzyme properties. This review shows how the coupled use of both tools …

Many eukaryotes are closely associated with bacteria which enable them to expand their
physiological capacities. Associations between algae (photosynthetic eukaryotes) and …

Antibiotics have revolutionised medicine in many aspects, and their discovery is considered
a turning point in human history. However, the most serious consequence of the use of …

The trillions of bacteria that make up the human microbiome are believed to encode
functions that are important to human health; however, little is known about the specific …

For decades, microbial natural products have been one of the major sources of novel drugs
for pharmaceutical companies, and today all evidence suggests that novel molecules with …