Advances of nanoparticles as drug delivery systems for disease diagnosis and treatment
Decades have passed since the first nanoparticles-base medicine was approved for human
cancer treatment, and the research and development of nanoparticles for drug delivery are …
cancer treatment, and the research and development of nanoparticles for drug delivery are …
The growth of siRNA-based therapeutics: Updated clinical studies
More than two decades after the natural gene-silencing mechanism of RNA interference was
elucidated, small interfering RNA (siRNA)-based therapeutics have finally broken into the …
elucidated, small interfering RNA (siRNA)-based therapeutics have finally broken into the …
Therapeutic siRNA: state of the art
ABSTRACT RNA interference (RNAi) is an ancient biological mechanism used to defend
against external invasion. It theoretically can silence any disease-related genes in a …
against external invasion. It theoretically can silence any disease-related genes in a …
[HTML][HTML] Pulmonary delivery of siRNA against acute lung injury/acute respiratory distress syndrome
M Zoulikha, Q **ao, GF Boafo, MA Sallam… - … Pharmaceutica Sinica B, 2022 - Elsevier
The use of small interfering RNAs (siRNAs) has been under investigation for the treatment of
several unmet medical needs, including acute lung injury/acute respiratory distress …
several unmet medical needs, including acute lung injury/acute respiratory distress …
Membrane‐destabilizing ionizable lipid empowered imaging‐guided siRNA delivery and cancer treatment
One of the imperative medical requirements for cancer treatment is how to establish an
imaging‐guided nanocarrier that combines therapeutic and imaging agents into one system …
imaging‐guided nanocarrier that combines therapeutic and imaging agents into one system …
In vivo gene delivery mediated by non-viral vectors for cancer therapy
R Mohammadinejad, A Dehshahri… - Journal of Controlled …, 2020 - Elsevier
Gene therapy by expression constructs or down-regulation of certain genes has shown great
potential for the treatment of various diseases. The wide clinical application of nucleic acid …
potential for the treatment of various diseases. The wide clinical application of nucleic acid …
Small interfering RNA: Discovery, pharmacology and clinical development—An introductory review
P Ranasinghe, ML Addison, JW Dear… - British Journal of …, 2023 - Wiley Online Library
Post‐transcriptional gene silencing targets and degrades mRNA transcripts, silencing the
expression of specific genes. RNA interference technology, using synthetic structurally well …
expression of specific genes. RNA interference technology, using synthetic structurally well …
A review of patisiran (ONPATTRO®) for the treatment of polyneuropathy in people with hereditary transthyretin amyloidosis
I Urits, D Swanson, MC Swett, A Patel, K Berardino… - Neurology and …, 2020 - Springer
Hereditary variant transthyretin amyloidosis (ATTRv) is a rare genetic defect that affects
about 5000–10,000 people worldwide, causing amyloidosis secondary to misfolding of …
about 5000–10,000 people worldwide, causing amyloidosis secondary to misfolding of …
The progress and promise of RNA medicine─ an arsenal of targeted treatments
In the past decade, there has been a shift in research, clinical development, and commercial
activity to exploit the many physiological roles of RNA for use in medicine. With the rapid …
activity to exploit the many physiological roles of RNA for use in medicine. With the rapid …
The current status of gene therapy for the treatment of cancer
TM Belete - Biologics: Targets and Therapy, 2021 - Taylor & Francis
Gene therapy is the administration of foreign genomic material into the host tissue to modify
the expression of a gene product or to change the biological properties of cells for …
the expression of a gene product or to change the biological properties of cells for …