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Site-specific transgene integration in chimeric antigen receptor (CAR) T cell therapies
Chimeric antigen receptor (CAR) T cells and natural killer (NK) cells are genetically
engineered immune cells that can detect target antigens on the surface of target cells and …
engineered immune cells that can detect target antigens on the surface of target cells and …
Molecular approaches to determine the multiplicity of Plasmodium infections
Multiplicity of infection (MOI), also termed complexity of infection (COI), is defined as the
number of genetically distinct parasite strains co-infecting a single host, which is an …
number of genetically distinct parasite strains co-infecting a single host, which is an …
Malaria molecular epidemiology: an evolutionary genetics perspective
Malaria is a vector-borne disease that involves multiple parasite species in a variety of
ecological settings. However, the parasite species causing the disease, the prevalence of …
ecological settings. However, the parasite species causing the disease, the prevalence of …
[HTML][HTML] The Diversity, Multiplicity of Infection and Population Structure of P. falciparum Parasites Circulating in Asymptomatic Carriers Living in High and Low Malaria …
Z Abukari, R Okonu, SB Nyarko, AC Lo, CC Dieng… - Genes, 2019 - mdpi.com
Background: Diversity in Plasmodium falciparum poses a major threat to malaria control and
elimination interventions. This study utilized 12 polymorphic microsatellite (MS) markers and …
elimination interventions. This study utilized 12 polymorphic microsatellite (MS) markers and …
Characterizing the malaria rural-to-urban transmission interface: The importance of reactive case detection
K Molina Gómez, MA Caicedo, A Gaitán… - PLoS neglected …, 2017 - journals.plos.org
Background Reported urban malaria cases are increasing in Latin America, however,
evidence of such trend remains insufficient. Here, we propose an integrated approach that …
evidence of such trend remains insufficient. Here, we propose an integrated approach that …
Genomes of Leishmania parasites directly sequenced from patients with visceral leishmaniasis in the Indian subcontinent
Whole genome sequencing (WGS) is increasingly used for molecular diagnosis and
epidemiology of infectious diseases. Current Leishmania genomic studies rely on DNA …
epidemiology of infectious diseases. Current Leishmania genomic studies rely on DNA …
Higher complexity of infection and genetic diversity of Plasmodium vivax than Plasmodium falciparum across all malaria transmission zones of Papua New Guinea
Plasmodium falciparum and Plasmodium vivax have varying transmission dynamics that are
informed by molecular epidemiology. This study aimed to determine the complexity of …
informed by molecular epidemiology. This study aimed to determine the complexity of …
Genetic Polymorphism of msp1 and msp2 in Plasmodium falciparum Isolates from Côte d'Ivoire versus Gabon
W Yavo, A Konaté, DP Mawili-Mboumba… - Journal of …, 2016 - Wiley Online Library
Introduction. The characterization of genetic profile of Plasmodium isolates from different
areas could help in better strategies for malaria elimination. This study aimed to compare P …
areas could help in better strategies for malaria elimination. This study aimed to compare P …
Multiplicity and molecular epidemiology of Plasmodium vivax and Plasmodium falciparum infections in East Africa
Background Parasite genetic diversity and multiplicity of infection (MOI) affect clinical
outcomes, response to drug treatment and naturally-acquired or vaccine-induced immunity …
outcomes, response to drug treatment and naturally-acquired or vaccine-induced immunity …
Extensive diversity in the allelic frequency of Plasmodium falciparum merozoite surface proteins and glutamate-rich protein in rural and urban settings of …
Background Nigeria carries a high burden of malaria which makes continuous surveillance
for current information on genetic diversity imperative. In this study, the merozoite surface …
for current information on genetic diversity imperative. In this study, the merozoite surface …