▪ Abstract DNA topoisomerases solve the topological problems associated with DNA
replication, transcription, recombination, and chromatin remodeling by introducing …

DNA topoisomerases are the magicians of the DNA world—by allowing DNA strands or
double helices to pass through each other, they can solve all of the topological problems of …

Double Holliday junctions (dHJS) are important intermediates of homologous
recombination. The separate junctions can each be cleaved by DNA structure-selective …

RecQ helicases are highly conserved from bacteria to man. Germline mutations in three of
the five known family members in humans give rise to debilitating disorders that are …

The RecQ helicases are conserved from bacteria to humans and play a critical role in
genome stability. In humans, loss of RecQ gene function is associated with cancer …

Abstract The Saccharomyces cerevisiae Sgs1 protein is a member of the RecQ family of
DNA helicases and is required for genome stability, but not cell viability. To identify proteins …

Members of the RecQ helicase family play critical roles in genome maintenance. There are
five RecQ homologs in mammals, and defects in three of these (BLM, WRN, and RECQL4) …

S-phase cells overcome chromosome lesions through replication-coupled recombination
processes that seem to be assisted by recombination-dependent DNA structures and/or …

DNA topoisomerases constitute a large family of enzymes that are essential for all domains
of life. Although they share general reaction chemistry and the capacity to govern DNA …

The RecQ DNA helicases, human BLM and yeast Sgs1, form a complex with topoisomerase
III (Top3) and are thought to act during DNA replication to restart forks that have paused due …