HOXA9 transcription factor is a double-edged sword: from development to cancer progression
The HOXA9 transcription factor serves as a molecular orchestrator in cancer stemness,
epithelial-mesenchymal transition (EMT), metastasis, and generation of the tumor …
epithelial-mesenchymal transition (EMT), metastasis, and generation of the tumor …
The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG
E Kugler, S Madiwale, D Yong, JAI Thoms… - Nature …, 2023 - nature.com
The ERG (ETS-related gene) transcription factor is linked to various types of cancer,
including leukemia. However, the specific ERG domains and co-factors contributing to …
including leukemia. However, the specific ERG domains and co-factors contributing to …
HOXA9 versus HOXB9; particular focus on their controversial role in tumor pathogenesis
The Homeobox (HOX) gene family is essential to regulating cellular processes because it
maintains the exact coordination required for tissue homeostasis, cellular differentiation, and …
maintains the exact coordination required for tissue homeostasis, cellular differentiation, and …
The CUT&RUN greenlist: genomic regions of consistent noise are effective normalizing factors for quantitative epigenome map**
FN de Mello, AC Tahira… - Briefings in …, 2024 - academic.oup.com
Abstract Cleavage Under Targets and Release Using Nuclease (CUT&RUN) is a recent
development for epigenome map**, but its unique methodology can hamper proper …
development for epigenome map**, but its unique methodology can hamper proper …
A novel t(X;21)(p11.4;q22.12) translocation adds to the role of BCOR and RUNX1 in myelodysplastic syndromes and acute myeloid leukemias
E Mavridou, AG Lema Fernandez… - Genes …, 2024 - Wiley Online Library
In myeloid neoplasms, both fusion genes and gene mutations are well‐established events
identifying clinicopathological entities. In this study, we present a thus far undescribed t (X; …
identifying clinicopathological entities. In this study, we present a thus far undescribed t (X; …
Aberrant stem cell and developmental programs in pediatric leukemia
RE Ling, JW Cross, A Roy - Frontiers in Cell and Developmental …, 2024 - frontiersin.org
Hematopoiesis is a finely orchestrated process, whereby hematopoietic stem cells give rise
to all mature blood cells. Crucially, they maintain the ability to self-renew and/or differentiate …
to all mature blood cells. Crucially, they maintain the ability to self-renew and/or differentiate …
Silencing with SAFB: a new role for HOXA9 in AML
AJ Deshpande, N Zhu - Blood, The Journal of the American …, 2023 - ashpublications.org
In this issue of Blood, Agrawal-Singh et al 1 uncover a novel mechanism by which HOXA9, a
transcription factor in acute myeloid leukemia (AML), represses gene expression through …
transcription factor in acute myeloid leukemia (AML), represses gene expression through …
Discovery of Chirally-dependent Protein O-2-Hydroxyglutarylation by D2HG and L2HG
Z Zhang, YK Liu, Z Luo, MJ Wu, CN Evans, Z Qu, F Xue… - bioRxiv, 2025 - biorxiv.org
Mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 are common in multiple types of
human cancer, leading to the accumulation of D-2-hydroxyglutarate (D2HG) and the …
human cancer, leading to the accumulation of D-2-hydroxyglutarate (D2HG) and the …
Molecular dynamics of myeloid progenitor transformation
ML Arcangeli, F Mazurier - Hématologie, 2023 - stm.cairn.info
Molecular dynamics of myeloid progenitor transformation | Cairn.info Cairn.info, Matières à
réflexion Cairn.info, Matières à réflexion Aucune suggestion trouvée Compte personnel …
réflexion Cairn.info, Matières à réflexion Aucune suggestion trouvée Compte personnel …