In the late 1960s, Barbaro and Zvaifler described a substance that caused antigen induced
histamine release from rabbit platelets producing antibodies in passive cutaneous …

“Platelet activating factor”(PAF) was coined in 1972 by Benveniste and collaborators' as the
name of a substance that was released from basophils after IgE stimulation. Various stimuli …

Cultured human endothelial cells produce platelet-activating factor (1-alkyl-2-acetyl-sn-
glycero-3-phosphocholine; PAF) when stimulated with human thrombin. The response to …

Murine tumor necrosis factor (mTNF) stimulates production of platelet-activating factor (PAF)
by cultured rat peritoneal macrophages in amounts comparable to those formed during …

The ether phospholipid composition of various tissues (brain, heart, lung, liver, kidney, testis,
erythrocytes and plasma) has been investigated in human, rat and guinea pig, using a new …

Many different mediators have been implicated in allergic responses and allergic diseases.
14 It is becoming increasingly apparent that no single mediator can account for allergic …

This study was done to determine whether human neutrophils contain sufficient 1-O-alkyl-2-
acyl-sn-glycero-3-phosphocholine to support the synthesis of platelet activating factor by a …

Platelet-activating factor is a phospholipid mediator of the allergic reaction that is a potent
stimulator of acute inflammatory processes. It is produced by various inflammatory cells …

This study was undertaken to determine if rabbit neutrophils contain sufficient ether-linked
precursor for the synthesis of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet …

Platelet-activating factor (PAF) is a potent inflammatory mediator that exerts its actions via
the single PAF receptor (PAF-R). Cells that biosynthesize alkyl-PAF also make abundant …