Organoids are simple tissue-engineered cell-based in vitro models that recapitulate many
aspects of the complex structure and function of the corresponding in vivo tissue. They can …

Organoids are in vitro miniaturized and simplified model systems of organs that have gained
enormous interest for modelling tissue development and disease, and for personalized …

Organoids—cellular aggregates derived from stem or progenitor cells that recapitulate organ
function in miniature—are of growing interest in developmental biology and medicine …

Organ‐and tissue‐level biological functions are intimately linked to microscale cell–cell
interactions and to the overarching tissue architecture. Together, biofabrication and …

There is growing need for a safe, efficient, specific and non-pathogenic means for delivery of
gene therapy materials. Nanomaterials for nucleic acid delivery offer an unprecedented …

Pattern recognition receptors (PRRs) and inflammasomes are a key part of the anti-viral
innate immune system as they detect conserved viral pathogen-associated molecular …

Induced pluripotent stem cell (iPSC)-derived organoids provide models to study human
organ development. Single-cell transcriptomics enable highly resolved descriptions of cell …

Understanding human organ formation is a scientific challenge with far-reaching medical
implications,. Three-dimensional stem-cell cultures have provided insights into human cell …

Human organoids, self-organized and differentiated from homogenous pluripotent stem cells
(PSC), replicate the key structural and functional characteristics of their in vivo counterparts …

Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …