Chimeric antigen receptor T-cell (CAR-T) therapy is the result of combining genetic
engineering-based cancer immunotherapy with adoptive cell therapy (ACT). CAR-T therapy …

G protein-coupled receptors (GPCRs) are the largest class of drug targets, largely owing to
their druggability, diversity and physiological efficacy. Many drugs selectively target specific …

The control over the extent and timing of G protein signaling is provided by the regulator of G
protein signaling (RGS) proteins that deactivate G protein α subunits (Gα). Mammalian …

G protein-coupled receptors (GPCRs) are cell-surface receptors that respond to various
stimuli to induce signalling pathways across cell membranes. Recent progress has yielded …

Optogenetics is the genetic approach for controlling cellular processes with light. It provides
spatiotemporal, quantitative and reversible control over biological signaling and metabolic …

Astrocytes respond to neurotransmitters and neuromodulators using G-protein-coupled
receptors (GPCRs) to mediate physiological responses. Despite their importance, there has …

Reagents that bind tightly and specifically to biomolecules of interest remain essential in the
exploration of biology and in their ultimate application to medicine. Besides ligands for …

Chimeric antigen receptor (CAR) T therapy represents a form of immune cellular therapy
with clinical efficacy and a specific target. A typical chimeric antigen receptor (CAR) …

The signal transduction by G-protein-coupled receptors (GPCRs) is mediated by
heterotrimeric G proteins composed from one of the 16 Gα subunits and the inseparable Gβγ …

G protein-coupled receptor kinase 2 (GRK2) is a central signaling node involved in the
modulation of many G protein-coupled receptors (GPCRs) and also displaying regulatory …