The recognition and sensing of biologically and environmentally important species has
emerged as a significant goal in the field of chemical sensors in recent years. 1Ā10 Several …

Proteins are major targets for radicals and two-electron oxidants in biological systems due to
their abundance and high rate constants for reaction. With highly reactive radicals damage …

There is a vast literature on the generation and effects of reactive oxygen species in
biological systems, both in relation to damage they cause and their involvement in cell …

Exposure of biological molecules to oxidants is inevitable and therefore commonplace.
Oxidative stress in cells arises from both external agents and endogenous processes that …

Neutrophils are essential for killing bacteria and other microorganisms, and they also have a
significant role in regulating the inflammatory response. Stimulated neutrophils activate their …

Exposure of cells to sublethal oxidative stress results in the modulation of various signaling
pathways. Oxidants can activate and inactivate transcription factors, membrane channels …

Significance: The release of myeloperoxidase (MPO) by activated leukocytes is critical in
innate immune responses. MPO produces hypochlorous acid (HOCl) and other strong …

Inflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal (GI) disorder
characterized by intestinal inflammation. The etiology of IBD is multifactorial and results from …

Review of myeloperoxidase supporting optimal microbicidal activity in the phagosomes of
human neutrophils. Successful immune defense requires integration of multiple effector …

The heme peroxidase family generates a battery of oxidants both for synthetic purposes, and
in the innate immune defence against pathogens. Myeloperoxidase (MPO) is the most …