Calprotectin: from biomarker to biological function

A Jukic, L Bakiri, EF Wagner, H Tilg, TE Adolph - Gut, 2021 - gut.bmj.com
The incidence of inflammatory bowel diseases (IBD) emerged with Westernisation of dietary
habits worldwide. Crohn's disease and ulcerative colitis are chronic debilitating conditions …

Emerging biomarkers for prediction and early diagnosis of necrotizing enterocolitis in the era of metabolomics and proteomics

E Agakidou, C Agakidis, H Gika, K Sarafidis - Frontiers in Pediatrics, 2020 - frontiersin.org
Necrotizing Enterocolitis (NEC) is a catastrophic disease affecting predominantly premature
infants and is characterized by high mortality and serious long-term consequences …

The use of fecal calprotectin testing in paediatric disorders: a position paper of the European Society for Paediatric Gastroenterology and Nutrition Gastroenterology …

CR Koninckx, E Donat, MA Benninga… - Journal of pediatric …, 2021 - journals.lww.com
Objectives: The aim of the study was to review the evidence regarding the clinical use and
value of fecal calprotectin (FC) measurements in different gastrointestinal disorders in …

Source of human milk (mother or donor) is more important than fortifier type (human or bovine) in sha** the preterm infant microbiome

SV Kumbhare, WD Jones, S Fast, C Bonner… - Cell Reports …, 2022 - cell.com
Milk fortifiers help meet the nutritional needs of preterm infants receiving their mother's own
milk (MOM) or donor human milk. We conducted a randomized clinical trial (NCT03214822) …

Biomarkers for the diagnosis of neonatal sepsis and necrotizing enterocolitis: Clinical practice guidelines

M Gilfillan, V Bhandari - Early human development, 2017 - Elsevier
Sepsis and necrotizing enterocolitis are major contributors to morbidity and mortality in
neonates, especially in those born preterm. While therapeutic interventions are available for …

Advances in paediatric gastroenterology

PKH Tam, PHY Chung, SD St Peter, CP Gayer… - The Lancet, 2017 - thelancet.com
Recent developments in paediatric gastrointestinal surgery have focused on minimally
invasive surgery, the accumulation of high-quality clinical evidence, and scientific research …

Changing the paradigm of defining, detecting, and diagnosing NEC: Perspectives on Bell's stages and biomarkers for NEC

SM Gephart, PV Gordon, AH Penn, KE Gregory… - Seminars in pediatric …, 2018 - Elsevier
Better means to diagnose and define necrotizing enterocolitis are needed to guide clinical
practice and research. Adequacy of Bell's staging system for clinical practice and clarity of …

Biomarkers of gut injury in neonates–where are we in predicting necrotising enterocolitis?

C Howarth, J Banerjee, S Eaton… - Frontiers in Pediatrics, 2022 - frontiersin.org
Despite advances in neonatal care Necrotising Enterocolitis (NEC) continues to have a
significant mortality and morbidity rate, and with increasing survival of those more immature …

Clinical characteristics and potential pathogenesis of cardiac necrotizing enterocolitis in neonates with congenital heart disease: a narrative review

KY Burge, A Gunasekaran, MM Makoni, AM Mir… - Journal of clinical …, 2022 - mdpi.com
Neonates with congenital heart disease (CHD) are at an increased risk of develo**
necrotizing enterocolitis (NEC), an acute inflammatory intestinal injury most commonly …

Biomarker discovery and utility in necrotizing enterocolitis

GP Goldstein, KG Sylvester - Clinics in perinatology, 2019 - perinatology.theclinics.com
Necrotizing enterocolitis (NEC) is a devastating disease of prematurity, with no current
method with sufficient sensitivity and specificity for early diagnosis. It affects approximately …