One of the central regulators of cellular and organismal metabolism in eukaryotes is AMP-
activated protein kinase (AMPK), which is activated when intracellular ATP production …

Protein lysine deacetylases have a pivotal role in numerous biological processes and can
be divided into the Rpd3/Hda1 and sirtuin families, each having members in diverse …

Summary Class IIa histone deacetylases (HDACs) are signal-dependent modulators of
transcription with established roles in muscle differentiation and neuronal survival. We show …

Acetylation of the [var epsilon]-amino group of a lysine residue was first discovered with
histones in 1968, but the responsible enzymes, histone acetyltransferases and …

The salt-inducible kinases, SIK1, SIK2 and SIK3, most closely resemble the AMP-activated
protein kinase (AMPK) and other AMPK-related kinases, and like these family members they …

The lineage-specific transcription factor (TF) MEF2C is often deregulated in leukemia.
However, strategies to target this TF have yet to be identified. Here, we used a domain …

Under fasting conditions, metazoans maintain energy balance by shifting from glucose to fat
burning. In the fasted state, SIRT1 promotes catabolic gene expression by deacetylating the …

In the last decade, the identification of enzymes that regulate acetylation of histones and
nonhistone proteins has revealed the key role of dynamic acetylation and deacetylation in …

During physical exercise, increases in motor neuron activity stimulate the expression of
muscle-specific genes through the myocyte enhancer factor 2 (MEF2) family of transcription …

In response to environmental cues, enzymes that influence the functions of proteins, through
reversible post-translational modifications supervise the coordination of cell behavior like …