[HTML][HTML] Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration

S Lyu, Z Dong, X Xu, HP Bei, HY Yuen, CWJ Cheung… - Bioactive materials, 2023 - Elsevier
Microneedle, as a novel drug delivery system, has attracted widespread attention due to its
non-invasiveness, painless and simple administration, controllable drug delivery, and …

Recent nanotechnologies to overcome the bacterial biofilm matrix barriers

X Lv, L Wang, A Mei, Y Xu, X Ruan, W Wang, J Shao… - Small, 2023 - Wiley Online Library
Bacterial biofilm‐related infectious diseases severely influence human health. Under typical
situations, pathogens can colonize inert or biological surfaces and form biofilms. Biofilms are …

Biofilm microenvironment triggered self-enhancing photodynamic immunomodulatory microneedle for diabetic wound therapy

L Yang, D Zhang, W Li, H Lin, C Ding, Q Liu… - Nature …, 2023 - nature.com
The treatment of diabetic wounds faces enormous challenges due to complex wound
environments, such as infected biofilms, excessive inflammation, and impaired …

Biofilm microenvironment-responsive nanoparticles for the treatment of bacterial infection

Y Hu, X Ruan, X Lv, Y Xu, W Wang, Y Cai, M Ding… - Nano Today, 2022 - Elsevier
Highlights•The biofilm formation process and its microenvironmental characteristics are
described.•Biofilm microenvironment-responsive nanoparticles for anti-infection are …

Bacterial anti-adhesion surface design: Surface patterning, roughness and wettability: A review

K Yang, J Shi, L Wang, Y Chen, C Liang, L Yang… - Journal of Materials …, 2022 - Elsevier
Bacterial adhesion and biofilm formation impose a heavy burden on the medical system.
Bacterial adhesion on implant materials would induce inflammation and result in implant …

Microneedle patches with antimicrobial and immunomodulating properties for infected wound healing

S Li, X Wang, Z Yan, T Wang, Z Chen… - Advanced …, 2023 - Wiley Online Library
Abstract Treatment of infected wounds remains a challenge owing to antibiotic resistance;
thus, develo** smart biomaterials for the healing of infected wounds is urgently needed. In …

Microneedles in drug delivery: progress and challenges

M Avcil, A Çelik - Micromachines, 2021 - mdpi.com
In recent years, an innovative transdermal delivery technology has attracted great interest for
its ability to distribute therapeutics and cosmeceuticals for several applications, including …

Advances in antimicrobial microneedle patches for combating infections

R Jamaledin, CKY Yiu, EN Zare, LN Niu… - Advanced …, 2020 - Wiley Online Library
Skin infections caused by bacteria, viruses and fungi are difficult to treat by conventional
topical administration because of poor drug penetration across the stratum corneum. This …

Microfluidic templated stem cell spheroid microneedles for diabetic wound treatment

X Wu, D Huang, Y Xu, G Chen, Y Zhao - Advanced Materials, 2023 - Wiley Online Library
Wound dressing patches based on stem cells have demonstrated promising potential in the
treatment of diabetic wounds, while their capabilities in the maintenance of cell stemness …

[PDF][PDF] Biofilms: formation, research models, potential targets, and methods for prevention and treatment

Y Su, JT Yrastorza, M Matis, J Cusick, S Zhao… - Advanced …, 2022 - Wiley Online Library
Due to the continuous rise in biofilm‐related infections, biofilms seriously threaten human
health. The formation of biofilms makes conventional antibiotics ineffective and dampens …