Protein structure prediction is a way to bridge the sequence-structure gap, one of the main
challenges in computational biology and chemistry. Predicting any protein's accurate …

Xenobiotic compounds are man-made compounds and widely used in dyes, drugs,
pesticides, herbicides, insecticides, explosives, and other industrial chemicals. These …

Clinical studies in a range of cancers have detected elevated levels of the Wnt antagonist
Dickkopf-1 (DKK1) in the serum or tumors of patients, and this was frequently associated …

Legume nodules create an environment for intracellular bacterial symbionts to fix
atmospheric nitrogen. The master regulator NODULE INCEPTION (NIN) controls many …

Routinely screened antibody fragments usually require further in vitro maturation to achieve
the desired biophysical properties. Blind in vitro strategies can produce improved ligands by …

Knowledge on protein folding has a profound impact on understanding the heterogeneity
and molecular function of proteins, further facilitating drug design. Predicting the 3D …

VHH, ie, VH domains of camelid single-chain antibodies, are very promising therapeutic
agents due to their significant physicochemical advantages compared to classical …

Apart from the canonical fingers, palm and thumb domains, the RNA dependent RNA
polymerases (RdRp) from the viral order Nidovirales possess two additional domains. Of …

Protein structure prediction based on comparative modeling is the most efficient way to
produce structural models when it can be performed. ORION is a dedicated webserver …

This paper describes the development and application of a suite of tools, called PBxplore, to
analyze the dynamics and deformability of protein structures using Protein Blocks (PBs) …