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The cell biology of ferroptosis
Ferroptosis is a non-apoptotic cell death mechanism characterized by iron-dependent
membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms …
membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms …
Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies
Q Zhou, Y Meng, D Li, L Yao, J Le, Y Liu… - Signal transduction and …, 2024 - nature.com
Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal
accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate …
accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate …
Targeting ferroptosis opens new avenues for the development of novel therapeutics
S Sun, J Shen, J Jiang, F Wang, J Min - Signal transduction and …, 2023 - nature.com
Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics,
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …
Regulation of ferroptosis by lipid metabolism
LE Pope, SJ Dixon - Trends in cell biology, 2023 - cell.com
Ferroptosis is an iron-dependent lethal mechanism that can be activated in disease and is a
proposed target for cancer therapy. Ferroptosis is defined by the overwhelming …
proposed target for cancer therapy. Ferroptosis is defined by the overwhelming …
[HTML][HTML] Ferroptosis at the intersection of lipid metabolism and cellular signaling
D Liang, AM Minikes, X Jiang - Molecular cell, 2022 - cell.com
Ferroptosis, a newly emerged form of regulated necrotic cell death, has been demonstrated
to play an important role in multiple diseases including cancer, neurodegeneration, and …
to play an important role in multiple diseases including cancer, neurodegeneration, and …
Targeting ferroptosis as a vulnerability in cancer
Ferroptosis is an iron-dependent form of regulated cell death that is triggered by the toxic
build-up of lipid peroxides on cellular membranes. In recent years, ferroptosis has garnered …
build-up of lipid peroxides on cellular membranes. In recent years, ferroptosis has garnered …
Ironing out the role of ferroptosis in immunity
Ferroptosis is a type of regulated cell death that drives the pathophysiology of many
diseases. Oxidative stress is detectable in many types of regulated cell death, but only …
diseases. Oxidative stress is detectable in many types of regulated cell death, but only …
The roles of ferroptosis in cancer: tumor suppression, tumor microenvironment, and therapeutic interventions
In cancer treatment, the recurrent challenge of inducing apoptosis through conventional
therapeutic modalities, often thwarted by therapy resistance, emphasizes the critical need to …
therapeutic modalities, often thwarted by therapy resistance, emphasizes the critical need to …
Ferroptosis as a potential target for cancer therapy
Ferroptosis is a recently discovered essential type of cell death that is mainly characterized
by iron overload and lipid peroxidation. Emerging evidence suggests that ferroptosis is a …
by iron overload and lipid peroxidation. Emerging evidence suggests that ferroptosis is a …
A guideline on the molecular ecosystem regulating ferroptosis
Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid
peroxidation, has garnered substantial interest since this term was first coined in 2012 …
peroxidation, has garnered substantial interest since this term was first coined in 2012 …