A researcher's guide to preclinical mouse NASH models
Non-alcoholic fatty liver disease (NAFLD) and its inflammatory form, non-alcoholic
steatohepatitis (NASH), have quickly risen to become the most prevalent chronic liver …
steatohepatitis (NASH), have quickly risen to become the most prevalent chronic liver …
Mechanisms of NAFLD development and therapeutic strategies
There has been a rise in the prevalence of nonalcoholic fatty liver disease (NAFLD),
paralleling a worldwide increase in diabetes and metabolic syndrome. NAFLD, a continuum …
paralleling a worldwide increase in diabetes and metabolic syndrome. NAFLD, a continuum …
[HTML][HTML] Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort☆
Background & Aims Genetic factors associated with non-alcoholic fatty liver disease
(NAFLD) remain incompletely understood. To date, most genome-wide association studies …
(NAFLD) remain incompletely understood. To date, most genome-wide association studies …
[HTML][HTML] Roles of the peroxisome proliferator-activated receptors (PPARs) in the pathogenesis of nonalcoholic fatty liver disease (NAFLD)
Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of disease phenotypes
which start with simple steatosis and lipid accumulation in the hepatocytes-a typical …
which start with simple steatosis and lipid accumulation in the hepatocytes-a typical …
[HTML][HTML] Contribution of adipose tissue inflammation to the development of type 2 diabetes mellitus
MS Burhans, DK Hagman, JN Kuzma… - Comprehensive …, 2018 - ncbi.nlm.nih.gov
The objective of this comprehensive review is to summarize and discuss the available
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …
[PDF][PDF] Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: systematic review and meta‐analysis
Liver fibrosis is the most important predictor of mortality in nonalcoholic fatty liver disease
(NAFLD). Quantitative risk of mortality by fibrosis stage has not been systematically …
(NAFLD). Quantitative risk of mortality by fibrosis stage has not been systematically …
Non-alcoholic steatohepatitis: a review of its mechanism, models and medical treatments
Non-alcoholic steatohepatitis (NASH) develops from non-alcoholic fatty liver disease
(NAFLD). Currently, around 25% of the population is estimated to have NAFLD, and 25% of …
(NAFLD). Currently, around 25% of the population is estimated to have NAFLD, and 25% of …
[HTML][HTML] Liver fibrosis
Liver fibrosis is a wound-healing response generated against an insult to the liver that
causes liver injury. It has the potential to progress into cirrhosis, and if not prevented, it may …
causes liver injury. It has the potential to progress into cirrhosis, and if not prevented, it may …
SGLT-2 inhibitors in NAFLD: expanding their role beyond diabetes and cardioprotection
Non-alcoholic fatty liver disease (NAFLD) is an 'umbrella'term, comprising a spectrum
ranging from benign, liver steatosis to non-alcoholic steatohepatitis, liver fibrosis and …
ranging from benign, liver steatosis to non-alcoholic steatohepatitis, liver fibrosis and …
Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice
B Xu, M Jiang, Y Chu, W Wang, D Chen, X Li… - Journal of …, 2018 - Elsevier
Background & Aims Gasdermin D (GSDMD)-executed programmed necrosis is involved in
inflammation and controls interleukin (IL)-1β release. However, the role of GSDMD in non …
inflammation and controls interleukin (IL)-1β release. However, the role of GSDMD in non …