While ventricular electromechanics is extensively studied in both physiological and
pathological conditions, four-chamber heart models have only been addressed recently; …

Physics-based computational models of the cardiovascular system are increasingly used to
simulate hemodynamics, tissue mechanics, and physiology in evolving healthy and …

We propose a mathematical and numerical model for the simulation of the heart function that
couples cardiac electrophysiology, active and passive mechanics and hemodynamics, and …

Numerical simulations are ubiquitous in mathematics and computational science. Several
industrial and clinical applications entail modeling complex multiphysics systems that evolve …

Computational fluid dynamics (CFD) is an important tool for the simulation of the
cardiovascular function and dysfunction. Due to the complexity of the anatomy, the …

Aortic stenosis, hypertension, and left ventricular hypertrophy often coexist in the elderly,
causing a detrimental mismatch in coupling between the heart and vasculature known as …

We propose a novel mathematical and numerical model for cardiac electromechanics,
wherein biophysically detailed core models describe the different physical processes …

We introduce a multiphysics and geometric multiscale computational model, suitable to
describe the hemodynamics of the whole human heart, driven by a four-chamber …

Background Modeling the whole cardiac function involves the solution of several complex
multi-physics and multi-scale models that are highly computationally demanding, which call …

Cardiac digital twins provide a physics and physiology informed framework to deliver
personalized medicine. However, high-fidelity multi-scale cardiac models remain a barrier to …