Vaccines have had a profound impact on the management and prevention of infectious
disease. In addition, the development of vaccines against chronic diseases has attracted …

Malaria is an illness caused by Plasmodium parasites transmitted to humans by infected
mosquitoes. Of the five species that infect humans, P. falciparum exacts the highest toll in …

Malaria is a severe disease caused by parasites of the genus Plasmodium, which is
transmitted to humans by a bite of an infected female mosquito of the species Anopheles …

Background The world has made great strides towards beating malaria, although about half
of the world population is still exposed to the risk of contracting malaria. Develo** an …

Immunity to malaria has been linked to the availability and function of helper CD4+ T cells,
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …

Background Development of an effective vaccine against the pathogenic blood-stage
infection of human malaria has proved challenging, and no candidate vaccine has affected …

Vaccines are one of the most powerful technologies supporting public health. The adaptive
immune response induced by immunization arises following appropriate activation and …

Malaria is a global public health burden with an estimated 229 million cases reported
worldwide in 2019. About 94% of the reported cases were recorded in the African region …

Background A blood-stage Plasmodium falciparum malaria vaccine would provide a second
line of defence to complement partially effective or waning immunity conferred by the …

There are no licensed vaccines against Plasmodium vivax. We conducted two phase 1/2a
clinical trials to assess two vaccines targeting P. vivax Duffy-binding protein region II …