A Delphi-method-based consensus guideline for definition of treatment-resistant depression for clinical trials

L Sforzini, C Worrell, M Kose, IM Anderson… - Molecular …, 2022 - nature.com
Criteria for treatment-resistant depression (TRD) and partially responsive depression (PRD)
as subtypes of major depressive disorder (MDD) are not unequivocally defined. In the …

Augmentation strategies for treatment resistant major depression: a systematic review and network meta-analysis

NA Nuñez, B Joseph, M Pahwa, R Kumar… - Journal of affective …, 2022 - Elsevier
Objective To compare the efficacy and discontinuation of augmentation agents in adult
patients with treatment-resistant depression (TRD). We conducted a systematic review and …

Treatment‐resistant depression: definition, prevalence, detection, management, and investigational interventions

RS McIntyre, M Alsuwaidan, BT Baune, M Berk… - World …, 2023 - Wiley Online Library
Treatment‐resistant depression (TRD) is common and associated with multiple serious
public health implications. A consensus definition of TRD with demonstrated predictive utility …

[HTML][HTML] The prevalence and national burden of treatment-resistant depression and major depressive disorder in the United States

M Zhdanava, D Pilon, I Ghelerter, W Chow… - The Journal of clinical …, 2021 - psychiatrist.com
Objective: Estimates of prevalence and burden of treatment-resistant depression (TRD) vary
widely in the literature. This study evaluated the prevalence and burden of TRD and the …

Adult ADHD and comorbid disorders: clinical implications of a dimensional approach

MA Katzman, TS Bilkey, PR Chokka, A Fallu… - BMC psychiatry, 2017 - Springer
Attention-deficit/hyperactivity disorder (ADHD) in the adult population is frequently
associated with comorbid psychiatric diseases that complicate its recognition, diagnosis and …

Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 clinical guidelines for the management of adults with major depressive disorder: section 3 …

SH Kennedy, RW Lam, RS McIntyre… - The Canadian …, 2016 - journals.sagepub.com
Background: The Canadian Network for Mood and Anxiety Treatments (CANMAT)
conducted a revision of the 2009 guidelines by updating the evidence and …

Real-world experience of esketamine use to manage treatment-resistant depression: a multicentric study on safety and effectiveness (REAL-ESK study)

G Martinotti, A Vita, A Fagiolini, G Maina… - Journal of Affective …, 2022 - Elsevier
Abstract Background Treatment-resistant Depression (TRD) represents a widespread
disorder with significant direct and indirect healthcare costs. esketamine, the S-enantiomer …

The burden of treatment-resistant depression: a systematic review of the economic and quality of life literature

KM Johnston, LC Powell, IM Anderson, S Szabo… - Journal of affective …, 2019 - Elsevier
Background Major depressive disorder (MDD) is a global public health concern. In
particular, treatment-resistant depression (TRD) represents a key unmet need in the …

Molecular mechanisms of psilocybin and implications for the treatment of depression

S Ling, F Ceban, LMW Lui, Y Lee, KM Teopiz… - CNS drugs, 2022 - Springer
Therapeutic deficiencies with monoaminergic antidepressants invites the need to identify
and develop novel rapid-acting antidepressants. Hitherto, ketamine and esketamine are …

Deep brain stimulation for treatment-resistant depression: an integrative review of preclinical and clinical findings and translational implications

MP Dandekar, AJ Fenoy, AF Carvalho, JC Soares… - Molecular …, 2018 - nature.com
Although deep brain stimulation (DBS) is an established treatment choice for Parkinson's
disease (PD), essential tremor and movement disorders, its effectiveness for the …