Short tandem repeats (STRs) are a class of repetitive elements, composed of tandem arrays
of 1–6 base pair sequence motifs, that comprise a substantial fraction of the human genome …

Polyglutamine (polyQ) spinocerebellar ataxias (SCAs) comprise a group of autosomal
dominant neurodegenerative disorders caused by (CAG/CAA) n expansions. The elongated …

Abstract Spinocerebellar ataxia type 7 (SCA7) is a progressive neurodegenerative disorder
resulting from abnormal expansion of an uninterrupted polyglutamine (polyQ) repeat in its …

Background Chronic intestinal pseudo-obstruction (CIPO) is a type of intestinal dysfunction
with symptoms of intestinal blockage but without the actual mechanical obstruction …

The cerebellum is a highly conserved brain compartment of vertebrates. Genetic diseases of
the human cerebellum often lead to degeneration of the principal neuron, the Purkinje cell …

Abstract The Allis group identified Gcn5 as the first transcription-related lysine
acetyltransferase in 1996, providing a molecular 'missing link'between chromatin …

Olfactory loss accompanies at least 139 neurological, somatic, and congenital/hereditary
conditions. This observation leads to the question of whether these associations are …

Interferon beta (IFNβ) is a member of the type-1 interferon family and has various
immunomodulatory functions in neuropathological conditions. Although the level of IFNβ is …

Recent advances in molecular science have significantly enlightened our mechanistic
understanding of spinocerebellar ataxia type 7. To further close remaining gaps, we …

Polyglutamine disorders are a complex group of incurable neurodegenerative disorders
caused by an abnormal expansion in the trinucleotide cytosine-adenine-guanine tract of the …