Computational tools to unmask transposable elements

P Goerner-Potvin, G Bourque - Nature Reviews Genetics, 2018 - nature.com
A substantial proportion of the genome of many species is derived from transposable
elements (TEs). Moreover, through various self-copying mechanisms, TEs continue to …

Identifying and mitigating bias in next-generation sequencing methods for chromatin biology

CA Meyer, XS Liu - Nature Reviews Genetics, 2014 - nature.com
Next-generation sequencing (NGS) technologies have been used in diverse ways to
investigate various aspects of chromatin biology by identifying genomic loci that are bound …

From telomere to telomere: The transcriptional and epigenetic state of human repeat elements

SJ Hoyt, JM Storer, GA Hartley, PGS Grady… - Science, 2022 - science.org
Mobile elements and repetitive genomic regions are sources of lineage-specific genomic
innovation and uniquely fingerprint individual genomes. Comprehensive analyses of such …

Atlas of subcellular RNA localization revealed by APEX-Seq

FM Fazal, S Han, KR Parker, P Kaewsapsak, J Xu… - Cell, 2019 - cell.com
We introduce APEX-seq, a method for RNA sequencing based on direct proximity labeling of
RNA using the peroxidase enzyme APEX2. APEX-seq in nine distinct subcellular locales …

The Dfam database of repetitive DNA families

R Hubley, RD Finn, J Clements, SR Eddy… - Nucleic acids …, 2016 - academic.oup.com
Repetitive DNA, especially that due to transposable elements (TEs), makes up a large
fraction of many genomes. Dfam is an open access database of families of repetitive DNA …

An atlas of human long non-coding RNAs with accurate 5′ ends

CC Hon, JA Ramilowski, J Harshbarger, N Bertin… - Nature, 2017 - nature.com
Long non-coding RNAs (lncRNAs) are largely heterogeneous and functionally
uncharacterized. Here, using FANTOM5 cap analysis of gene expression (CAGE) data, we …

Analyses of 600+ insect genomes reveal repetitive element dynamics and highlight biodiversity-scale repeat annotation challenges

JS Sproul, S Hotaling, J Heckenhauer… - Genome …, 2023 - genome.cshlp.org
Repetitive elements (REs) are integral to the composition, structure, and function of
eukaryotic genomes, yet remain understudied in most taxonomic groups. We investigated …

Sequence diversity analyses of an improved rhesus macaque genome enhance its biomedical utility

WC Warren, RA Harris, M Haukness, IT Fiddes… - Science, 2020 - science.org
INTRODUCTION The rhesus macaque (Macaca mulatta) is one of the most widely used
nonhuman primate (NHP) models for studying human biology and disease. As a …

The Dfam community resource of transposable element families, sequence models, and genome annotations

J Storer, R Hubley, J Rosen, TJ Wheeler, AF Smit - Mobile DNA, 2021 - Springer
Dfam is an open access database of repetitive DNA families, sequence models, and
genome annotations. The 3.0–3.3 releases of Dfam (https://dfam. org) represent an evolution …

nhmmer: DNA homology search with profile HMMs

TJ Wheeler, SR Eddy - Bioinformatics, 2013 - academic.oup.com
Sequence database searches are an essential part of molecular biology, providing
information about the function and evolutionary history of proteins, RNA molecules and DNA …