Computational tools to unmask transposable elements
A substantial proportion of the genome of many species is derived from transposable
elements (TEs). Moreover, through various self-copying mechanisms, TEs continue to …
elements (TEs). Moreover, through various self-copying mechanisms, TEs continue to …
Identifying and mitigating bias in next-generation sequencing methods for chromatin biology
Next-generation sequencing (NGS) technologies have been used in diverse ways to
investigate various aspects of chromatin biology by identifying genomic loci that are bound …
investigate various aspects of chromatin biology by identifying genomic loci that are bound …
From telomere to telomere: The transcriptional and epigenetic state of human repeat elements
SJ Hoyt, JM Storer, GA Hartley, PGS Grady… - Science, 2022 - science.org
Mobile elements and repetitive genomic regions are sources of lineage-specific genomic
innovation and uniquely fingerprint individual genomes. Comprehensive analyses of such …
innovation and uniquely fingerprint individual genomes. Comprehensive analyses of such …
Atlas of subcellular RNA localization revealed by APEX-Seq
We introduce APEX-seq, a method for RNA sequencing based on direct proximity labeling of
RNA using the peroxidase enzyme APEX2. APEX-seq in nine distinct subcellular locales …
RNA using the peroxidase enzyme APEX2. APEX-seq in nine distinct subcellular locales …
The Dfam database of repetitive DNA families
Repetitive DNA, especially that due to transposable elements (TEs), makes up a large
fraction of many genomes. Dfam is an open access database of families of repetitive DNA …
fraction of many genomes. Dfam is an open access database of families of repetitive DNA …
An atlas of human long non-coding RNAs with accurate 5′ ends
Long non-coding RNAs (lncRNAs) are largely heterogeneous and functionally
uncharacterized. Here, using FANTOM5 cap analysis of gene expression (CAGE) data, we …
uncharacterized. Here, using FANTOM5 cap analysis of gene expression (CAGE) data, we …
Analyses of 600+ insect genomes reveal repetitive element dynamics and highlight biodiversity-scale repeat annotation challenges
Repetitive elements (REs) are integral to the composition, structure, and function of
eukaryotic genomes, yet remain understudied in most taxonomic groups. We investigated …
eukaryotic genomes, yet remain understudied in most taxonomic groups. We investigated …
Sequence diversity analyses of an improved rhesus macaque genome enhance its biomedical utility
INTRODUCTION The rhesus macaque (Macaca mulatta) is one of the most widely used
nonhuman primate (NHP) models for studying human biology and disease. As a …
nonhuman primate (NHP) models for studying human biology and disease. As a …
The Dfam community resource of transposable element families, sequence models, and genome annotations
Dfam is an open access database of repetitive DNA families, sequence models, and
genome annotations. The 3.0–3.3 releases of Dfam (https://dfam. org) represent an evolution …
genome annotations. The 3.0–3.3 releases of Dfam (https://dfam. org) represent an evolution …
nhmmer: DNA homology search with profile HMMs
Sequence database searches are an essential part of molecular biology, providing
information about the function and evolutionary history of proteins, RNA molecules and DNA …
information about the function and evolutionary history of proteins, RNA molecules and DNA …