The innate immune response provides the first line of defense against invading pathogens,
and immune disorders cause a variety of diseases. The fruit fly Drosophila melanogaster …

Salmonella species can infect a diverse range of birds, reptiles, and mammals, including
humans. The type III protein secretion system (T3SS) encoded by Salmonella pathogenicity …

Background: The gut microbiota is a diverse community of microbes that maintain the
stability of the intestinal environment. Dysbiosis of the gut microbiota has been linked to …

Because nuclear factor-κB (NF-κB) is a ubiquitously expressed proinflammatory transcription
factor that regulates the expression of over 500 genes involved in cellular transformation …

Necrotizing enterocolitis (NEC) is a devastating intestinal disorder characterized by
intestinal inflammation and necrosis. 1 This disease is one of the most common …

Although genes contribute to colorectal cancer, the gut microbiota are an important player.
Accumulating evidence suggests that chronic infection and the ensuing inflammation …

Necrotising enterocolitis is one of the most common gastrointestinal emergencies in
newborn infants. Here we review the epidemiology, clinical presentation, and …

Salmonellae are important causes of enteric diseases in all vertebrates. Characterization of
the molecular mechanisms that underpin the interactions of salmonellae with their animal …

The nuclear factor-κB (NF-κB) family of transcription factors plays a central part in the host
response to infection by microbial pathogens, by orchestrating the innate and acquired host …

Viral and microbial infections often elicit programmed cell death as part of the host defense
system or as a component of the survival strategy of the pathogen. It is thus not surprising …