Cytokines are small signaling proteins that have central roles in inflammation and cell
survival. In the half-century since the discovery of the first cytokines, the interferons, over fifty …

Molecule representation learning (MRL) has been extensively studied and current methods
have shown promising power for various tasks, eg, molecular property prediction and target …

HIV-1 integrase (IN) is one of three essential enzymes (along with reverse transcriptase and
protease) encoded by the viral pol gene. IN mediates two critical reactions during viral …

Integrase is essential for human immunodeficiency virus–type 1 (HIV-1) replication;
however, potent inhibition of the isolated enzyme in biochemical assays has not readily …

Water soluble extracts of the herbal plant, Salvia miltiorrhiza (Danshen) exhibited potent
effect against HIV-1 integrase activity in vitro and viral replication in vivo. We have …

Nanotoxicology studies toxicity of nanomaterials and has been widely applied in biomedical
researches to explore toxicity of various biological systems. Investigating biological systems …

Despite the success of protease and reverse transcriptase inhibitors, new drugs to suppress
HIV-1 replication are still needed. Several other early events in the viral life cycle (stages …

For the purpose of discovering anti-HIV-1 agents from natural sources, water and EtOH
extracts of 50 Thai plants were screened for their inhibitory activity against HIV-1 integrase …

Integrase (IN) strand transfer inhibitors (INSTIs) are recent compounds in the antiretroviral
arsenal used against HIV. INSTIs work by blocking retroviral integration; an essential step in …

We present the solution structure of MAP30, a plant protein with anti-HIV and anti-tumor
activities. Structural analysis and subsequent biochemical assays lead to several novel …