Sperm selection for ICSI: do we have a winner?

D Baldini, D Ferri, GM Baldini, D Lot, A Catino… - Cells, 2021‏ - mdpi.com
In assisted reproductive technology (ART), the aim of sperm cells' preparation is to select
competent spermatozoa with the highest fertilization potential and in this context, the …

Caspases: the executioners of apoptosis

GM Cohen - Biochemical Journal, 1997‏ - portlandpress.com
Apoptosis is a major form of cell death, characterized initially by a series of stereotypic
morphological changes. In the nematode Caenorhabditis elegans, the gene ced-3 encodes …

[HTML][HTML] Ischemic cell death in brain neurons

P Lipton - Physiological reviews, 1999‏ - journals.physiology.org
This review is directed at understanding how neuronal death occurs in two distinct insults,
global ischemia and focal ischemia. These are the two principal rodent models for human …

Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and …

WH Wilson, OA O'Connor, MS Czuczman… - The lancet …, 2010‏ - thelancet.com
Background Proteins of the BCL-2 family regulate clonal selection and survival of
lymphocytes, and are frequently overexpressed in lymphomas. Navitoclax is a targeted high …

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

G Koopman, CP Reutelingsperger, GA Kuijten… - 1994‏ - ashpublications.org
Apoptosis, or programmed cell death, is a general mechanism for removal of unwanted cells
from the immune system. It is characterized by chromatin condensation, a reduction in cell …

Shigella flexneri induces apoptosis in infected macrophages

A Zychlinsky, MC Prevost, PJ Sansonetti - Nature, 1992‏ - nature.com
THE Gram-negative bacterial pathogen Shigella flexneri causes dysentery by invading the
human colonic mucosa1. Bacteria are phagocytosed by enterocytes2, escape from the …

The mitochondrial membrane potential (Δψm) in apoptosis; an update

JD Ly, DR Grubb, A Lawen - Apoptosis, 2003‏ - Springer
Mitochondrial dysfunction has been shown to participate in the induction of apoptosis and
has even been suggested to be central to the apoptotic pathway. Indeed, opening of the …

Apoptosis. Its significance in cancer and cancer therapy

JFR Kerr, CM Winterford, BV Harmon - Cancer, 1994‏ - Wiley Online Library
Apoptosis is a distinct mode of cell death that is responsible for deletion of cells in normal
tissues; it also occurs in specific pathologic contexts. Morphologically, it involves rapid …

Epidemiology, demographics, and pathophysiology of acute spinal cord injury

LHS Sekhon, MG Fehlings - Spine, 2001‏ - journals.lww.com
Spinal cord injury occurs through various countries throughout the world with an annual
incidence of 15 to 40 cases per million, with the causes of these injuries ranging from motor …

Induction of apoptosis by cancer chemotherapy

SH Kaufmann, WC Earnshaw - Experimental cell research, 2000‏ - Elsevier
Studies performed over the past five years have demonstrated that there are two major cell-
intrinsic pathways for inducing apoptosis, one that begins with ligation of cell surface death …