Management of complicated diaphragmatic hernia in the acute setting: a WSES position paper

M Giuffrida, G Perrone, F Abu-Zidan, V Agnoletti… - World Journal of …, 2023‏ - Springer
Background Diaphragmatic hernia (DH) presenting acutely can be a potentially life-
threatening condition. Its management continues to be debatable. Methods A bibliographic …

Clinical applications of human organoids

MMA Verstegen, RP Coppes, A Beghin, P De Coppi… - Nature Medicine, 2025‏ - nature.com
Organoids are innovative three-dimensional and self-organizing cell cultures of various
lineages that can be used to study diverse tissues and organs. Human organoids have …

Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids

MFM Gerli, G Calà, MA Beesley, B Sina, L Tullie… - Nature Medicine, 2024‏ - nature.com
Isolation of tissue-specific fetal stem cells and derivation of primary organoids is limited to
samples obtained from termination of pregnancies, hampering prenatal investigation of fetal …

Fetal hypoplastic lungs have multilineage inflammation that is reversed by amniotic fluid stem cell extracellular vesicle treatment

L Antounians, RL Figueira, B Kukreja, ML Litvack… - Science …, 2024‏ - science.org
Antenatal administration of extracellular vesicles from amniotic fluid stem cells (AFSC-EVs)
reverses features of pulmonary hypoplasia in models of congenital diaphragmatic hernia …

Effects of spinal deformities on lung development in children: a review

Y Wang, D Wang, G Zhang, B Ma, Y Ma, Y Yang… - Journal of orthopaedic …, 2023‏ - Springer
Scoliosis before the age of 5 years is referred to as early-onset scoliosis (EOS). While
causes may vary, EOS can potentially affect respiratory function and lung development as …

Amniotic fluid stem cell extracellular vesicles promote lung development via TGF-beta modulation in a fetal rat model of oligohydramnios

F Doktor, RL Figueira, V Fortuna, G Biouss… - Journal of Controlled …, 2025‏ - Elsevier
Oligohydramnios (decreased amniotic fluid volume for gestational age) is a severe condition
associated with high morbidity and mortality mainly due to fetal pulmonary hypoplasia …

Connecting clinical, environmental, and genetic factors point to an essential role for vitamin A signaling in the pathogenesis of congenital diaphragmatic hernia

RM Gilbert, JP Gleghorn - American Journal of Physiology …, 2023‏ - journals.physiology.org
Congenital diaphragmatic hernia (CDH) is a developmental disorder that results in
incomplete diaphragm formation, pulmonary hypoplasia, and pulmonary hypertension …

Diagnosis & management of pulmonary hypertension in congenital diaphragmatic hernia

S Bhombal, N Patel - Seminars in Fetal and Neonatal Medicine, 2022‏ - Elsevier
Congenital diaphragmatic hernia (CDH) contributes to neonatal morbidity and mortality
worldwide. Pulmonary hypertension (PH) is a key component of CDH pathophysiology and …

Exploring new perspectives on congenital diaphragmatic hernia: A comprehensive review

W Renik-Jankowska, A Buczyńska… - … et Biophysica Acta (BBA …, 2024‏ - Elsevier
Congenital diaphragmatic hernia (CDH) represents a developmental anomaly that
profoundly impacts the embryonic development of both the respiratory and cardiovascular …

The brain of fetuses with congenital diaphragmatic hernia shows signs of hypoxic injury with loss of progenitor cells, neurons, and oligodendrocytes

G Biouss, L Antounians, J Aguet, K Kopcalic… - Scientific Reports, 2024‏ - nature.com
Congenital diaphragmatic hernia (CDH) is a birth defect characterized by incomplete
closure of the diaphragm, herniation of abdominal organs into the chest, and compression of …