Glycoconjugates: synthesis, functional studies, and therapeutic developments

SS Shivatare, VS Shivatare, CH Wong - Chemical reviews, 2022 - ACS Publications
Glycoconjugates are major constituents of mammalian cells that are formed via covalent
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …

The glycosylation in SARS-CoV-2 and its receptor ACE2

Y Gong, S Qin, L Dai, Z Tian - Signal Transduction and Targeted …, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19), a highly infectious disease caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected more than …

Primary structure of glycans by NMR spectroscopy

C Fontana, G Widmalm - Chemical reviews, 2023 - ACS Publications
Glycans, carbohydrate molecules in the realm of biology, are present as biomedically
important glycoconjugates and a characteristic aspect is that their structures in many …

AlphaFold 2 and NMR spectroscopy: partners to understand protein structure, dynamics and function

DV Laurents - Frontiers in molecular biosciences, 2022 - frontiersin.org
The artificial intelligence program AlphaFold 2 is revolutionizing the field of protein structure
determination as it accurately predicts the 3D structure of two thirds of the human proteome …

Glycosylation of SARS-CoV-2: structural and functional insights

A Shajahan, LE Pepi, DS Rouhani, C Heiss… - Analytical and …, 2021 - Springer
The COVID-19 pandemic is caused by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2). Similar to other coronaviruses, its particles are composed of four structural …

Glycans of SARS-CoV-2 spike protein in virus infection and antibody production

X Zhao, H Chen, H Wang - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
Viral protein glycosylation represents a successful strategy employed by the parasite to take
advantage of host–cell machinery for modification of its own proteins. The resulting glycans …

Novel galectin-3 roles in neurogenesis, inflammation and neurological diseases

LC Soares, O Al-Dalahmah, J Hillis, CC Young, I Asbed… - Cells, 2021 - mdpi.com
Galectin-3 (Gal-3) is an evolutionarily conserved and multifunctional protein that drives
inflammation in disease. Gal-3's role in the central nervous system has been less studied …

Protein post-translational modification in SARS-CoV-2 and host interaction

N Cheng, M Liu, W Li, BY Sun, D Liu, G Wang… - Frontiers in …, 2023 - frontiersin.org
SARS-CoV-2 can cause lung diseases, such as pneumonia and acute respiratory distress
syndrome, and multi-system dysfunction. Post-translational modifications (PTMs) related to …

Glycosylation is a key in SARS-CoV-2 infection

CA Reis, R Tauber, V Blanchard - Journal of Molecular Medicine, 2021 - Springer
SARS-CoV-2 causes the respiratory syndrome COVID-19 and is responsible for the current
pandemic. The S protein of SARS-CoV-2-mediating virus binding to target cells and …

Pathogen-sugar interactions revealed by universal saturation transfer analysis

CJ Buchanan, B Gaunt, PJ Harrison, Y Yang, J Liu… - Science, 2022 - science.org
Many pathogens exploit host cell-surface glycans. However, precise analyses of glycan
ligands binding with heavily modified pathogen proteins can be confounded by overlap** …