[HTML][HTML] Revisiting metallodrugs for the treatment of skin cancers
CM Manzano, DH Nakahata, REF de Paiva - Coordination Chemistry …, 2022 - Elsevier
Metallodrugs were classically screened against skin cancer (either in vitro or in vivo) at the
peak of the development of platinum anticancer agents. New systematic studies appeared in …
peak of the development of platinum anticancer agents. New systematic studies appeared in …
Factors that influence singlet oxygen formation vs. ligand substitution for light-activated ruthenium anticancer compounds
This review focuses on light-activated ruthenium anticancer compounds and the factors that
influence which pathway is favored. Photodynamic therapy (PDT) is favored by π expansion …
influence which pathway is favored. Photodynamic therapy (PDT) is favored by π expansion …
Intraligand excited states turn a ruthenium oligothiophene complex into a light-triggered Ubertoxin with anticancer effects in extreme hypoxia
Ru (II) complexes that undergo photosubstitution reactions from triplet metal-centered (3MC)
excited states are of interest in photochemotherapy (PCT) due to their potential to produce …
excited states are of interest in photochemotherapy (PCT) due to their potential to produce …
Near-infrared absorbing Ru (ii) complexes act as immunoprotective photodynamic therapy (PDT) agents against aggressive melanoma
Mounting evidence over the past 20 years suggests that photodynamic therapy (PDT), an
anticancer modality known mostly as a local treatment, has the capacity to invoke a systemic …
anticancer modality known mostly as a local treatment, has the capacity to invoke a systemic …
Ir (III) Half-Sandwich Photosensitizers with a π-Expansive Ligand for Efficient Anticancer Photodynamic Therapy
C Gonzalo-Navarro, E Zafon, JA Organero… - Journal of Medicinal …, 2024 - ACS Publications
One approach to reduce the side effects of chemotherapy in cancer treatment is
photodynamic therapy (PDT), which allows spatiotemporal control of the cytotoxicity. We …
photodynamic therapy (PDT), which allows spatiotemporal control of the cytotoxicity. We …
Design of a tris-heteroleptic Ru (II) complex with red-light excitation and remarkably improved photobiological activity
S Li, J Zhao, X Wang, G Xu, S Gou, Q Zhao - Inorganic Chemistry, 2020 - ACS Publications
Ru (II)-polypyridyl complexes are of increasing interest in photodynamic therapy (PDT) due
to their easily tunable photophysical and photochemical properties. However, short …
to their easily tunable photophysical and photochemical properties. However, short …
Phototoxicity of Tridentate Ru (II) Polypyridyl Complex with Expanded Bite Angles toward Mammalian Cells and Multicellular Tumor Spheroids
Tridentate ligand-coordinated ruthenium (II) polypyridyl complexes with large N–Ru–N bite
angles have been shown to promote ligand field splitting and reduce singlet–triplet state …
angles have been shown to promote ligand field splitting and reduce singlet–triplet state …
Trifluoromethyl substitution enhances photoinduced activity against breast cancer cells but reduces ligand exchange in Ru (II) complex
A series of five ruthenium complexes containing triphenyl phosphine groups known to
enhance both cellular penetration and photoinduced ligand exchange, cis-[Ru (bpy) 2 (P …
enhance both cellular penetration and photoinduced ligand exchange, cis-[Ru (bpy) 2 (P …
Bis [pyrrolyl Ru (ii)] triads: a new class of photosensitizers for metal–organic photodynamic therapy
DA Smithen, S Monro, M Pinto, J Roque… - Chemical …, 2020 - pubs.rsc.org
A new family of ten dinuclear Ru (II) complexes based on the bis [pyrrolyl Ru (II)] triad
scaffold, where two Ru (bpy) 2 centers are separated by a variety of organic linkers, was …
scaffold, where two Ru (bpy) 2 centers are separated by a variety of organic linkers, was …
Ruthenium (II) polypyridyl complexes with π-expansive ligands: synthesis and cubosome encapsulation for photodynamic therapy of non-melanoma skin cancer
In photodynamic therapy (PDT), Ru (II) polypyridyl complexes (RPCs) featuring the popular
π-expansive benzo [i] dipyrido [3, 2-a: 2′, 3′-c] phenazine (dppn) ligand have attracted …
π-expansive benzo [i] dipyrido [3, 2-a: 2′, 3′-c] phenazine (dppn) ligand have attracted …