Lipid nanoparticle-mediated drug delivery to the brain

P Khare, SX Edgecomb, CM Hamadani… - Advanced Drug Delivery …, 2023 - Elsevier
Lipid nanoparticles (LNPs) have revolutionized the field of drug delivery through their
applications in siRNA delivery to the liver (Onpattro) and their use in the Pfizer-BioNTech …

Multifunctional nanotheranostics for near infrared optical imaging-guided treatment of brain tumors

L Zhang, Y Liu, H Huang, H **e, B Zhang, W **a… - Advanced drug delivery …, 2022 - Elsevier
Malignant brain tumors, a heterogeneous group of primary and metastatic neoplasms in the
central nervous system (CNS), are notorious for their highly invasive and devastating …

Overcoming blood–brain barrier transport: Advances in nanoparticle-based drug delivery strategies

S Ding, AI Khan, X Cai, Y Song, Z Lyu, D Du, P Dutta… - Materials today, 2020 - Elsevier
The blood–brain barrier (BBB), a unique structure in the central nervous system (CNS),
protects the brain from bloodborne pathogens by its excellent barrier properties …

Triple conjugated carbon dots as a nano-drug delivery model for glioblastoma brain tumors

SD Hettiarachchi, RM Graham, KJ Mintz, Y Zhou… - Nanoscale, 2019 - pubs.rsc.org
Most of the dual nano drug delivery systems fail to enter malignant brain tumors due to a
lack of proper targeting systems and the size increase of the nanoparticles after drug …

Lactoferrin's anti-cancer properties: Safety, selectivity, and wide range of action

A Cutone, L Rosa, G Ianiro, MS Lepanto… - Biomolecules, 2020 - mdpi.com
Despite recent advances in cancer therapy, current treatments, including radiotherapy,
chemotherapy, and immunotherapy, although beneficial, present attendant side effects and …

Lactoferrin, a multi-functional glycoprotein: Active therapeutic, drug nanocarrier & targeting ligand

AO Elzoghby, MA Abdelmoneem, IA Hassanin… - Biomaterials, 2020 - Elsevier
Recent progress in protein-based nanomedicine, inspired by the success of Abraxane®
albumin-paclitaxel nanoparticles, have resulted in novel therapeutics used for treatment of …

Emerging strategies to fabricate polymeric nanocarriers for enhanced drug delivery across blood-brain barrier: an overview

YH Song, R De, KT Lee - Advances in Colloid and Interface Science, 2023 - Elsevier
Blood-brain barrier (BBB) serves as an essential interface between central nervous system
(CNS) and its periphery, allowing selective permeation of ions, gaseous molecules, and …

[HTML][HTML] Efficient delivery of Temozolomide using ultrasmall large-pore silica nanoparticles for glioblastoma

TI Janjua, Y Cao, A Ahmed-Cox, A Raza… - Journal of Controlled …, 2023 - Elsevier
The prognosis of brain cancers such as glioblastoma remains poor despite numerous
advancements in the field of neuro-oncology. The presence of the blood brain barrier (BBB) …

Nanoparticle drug delivery system for glioma and its efficacy improvement strategies: a comprehensive review

J Li, J Zhao, T Tan, M Liu, Z Zeng, Y Zeng… - International Journal …, 2020 - Taylor & Francis
Gliomas are the most common tumor of the central nervous system. However, the presence
of the brain barrier blocks the effective delivery of drugs and leads to the treatment failure of …

[HTML][HTML] Applications of various types of nanomaterials for the treatment of neurological disorders

A Waris, A Ali, AU Khan, M Asim, D Zamel, K Fatima… - Nanomaterials, 2022 - mdpi.com
Neurological disorders (NDs) are recognized as one of the major health concerns globally.
According to the World Health Organization (WHO), neurological disorders are one of the …