Emerging role of GLP-1 agonists in obesity: a comprehensive review of randomised controlled trials

MS Popoviciu, L Păduraru, G Yahya… - International journal of …, 2023‏ - mdpi.com
Obesity is a chronic disease with high prevalence and associated comorbidities, making it a
growing global concern. These comorbidities include type 2 diabetes, hypertension …

Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics

SA Polyzos, J Kountouras, CS Mantzoros - Metabolism, 2019‏ - Elsevier
The obesity epidemic is closely associated with the rising prevalence and severity of
nonalcoholic fatty liver disease (NAFLD): obesity has been linked not only with simple …

Long-term efficacy and safety of anti-obesity treatment: where do we stand?

YJ Tak, SY Lee - Current obesity reports, 2021‏ - Springer
Abstract Purpose of Review As a chronic and relapsing disease, obesity impairs metabolism
and causes cardiovascular diseases. Although behavioral modification is important for the …

Association of glucagon-like peptide-1 receptor agonist use with risk of gallbladder and biliary diseases: a systematic review and meta-analysis of randomized clinical …

L He, J Wang, F **, N Yang, J Huang… - JAMA internal …, 2022‏ - jamanetwork.com
Importance Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been widely
recommended for glucose control and cardiovascular risk reduction in patients with type 2 …

Management of hyperglycemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study …

MJ Davies, DA D'Alessio, J Fradkin, WN Kernan… - Diabetes …, 2018‏ - pmc.ncbi.nlm.nih.gov
The American Diabetes Association and the European Association for the Study of Diabetes
convened a panel to update the prior position statements, published in 2012 and 2015, on …

Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the …

MJ Davies, DA D'Alessio, J Fradkin, WN Kernan… - Diabetologia, 2018‏ - Springer
Abstract The American Diabetes Association and the European Association for the Study of
Diabetes convened a panel to update the prior position statements, published in 2012 and …

GLP-1 receptor agonists (GLP-1RAs): cardiovascular actions and therapeutic potential

X Ma, Z Liu, I Ilyas, PJ Little, D Kamato… - … journal of biological …, 2021‏ - pmc.ncbi.nlm.nih.gov
Type 2 diabetes mellitus (T2DM) is closely associated with cardiovascular diseases (CVD),
including atherosclerosis, hypertension and heart failure. Some anti-diabetic medications …

Gastrointestinal adverse events associated with semaglutide: a pharmacovigilance study based on FDA adverse event reporting system

Y Shu, X He, P Wu, Y Liu, Y Ding, Q Zhang - Frontiers in public health, 2022‏ - frontiersin.org
Background Semaglutide was approved for treatment of type 2 diabetes mellitus (T2DM)
and chronic weight management in obesity or overweight adults. However, real-world data …

The relationship between diabetes mellitus and cancers and its underlying mechanisms

B Zhu, S Qu - Frontiers in Endocrinology, 2022‏ - frontiersin.org
Epidemiological studies suggest associations between diabetes mellitus and some cancers.
The risk of a number of cancers appears to be increased in diabetes mellitus. On the other …

Combining glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) in patients with type 2 diabetes mellitus …

P Gourdy, P Darmon, F Dievart, JM Halimi… - Cardiovascular …, 2023‏ - Springer
Due to their cardiovascular protective effect, glucagon-like peptide-1 receptor agonists (GLP-
1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2is) represent breakthrough …