Microtechnology-based in vitro models: Mimicking liver function and pathophysiology
The liver plays important roles in drug metabolism and homeostasis. The metabolism and
biotransformation can not only affect the efficacy of drugs but also result in hepatotoxicity …
biotransformation can not only affect the efficacy of drugs but also result in hepatotoxicity …
An overview on the manufacturing of functional and mature cellular skin substitutes
M Ríos-Galacho, D Martínez-Moreno… - … Engineering Part B …, 2022 - liebertpub.com
There are different types of skin diseases due to chronic injuries that impede the natural
healing process of the skin. Tissue engineering has focused on the development of …
healing process of the skin. Tissue engineering has focused on the development of …
A virtual scalable model of the Hepatic Lobule for acetaminophen hepatotoxicity prediction
Addressing drug-induced liver injury is crucial in drug development, often causing Phase III
trial failures and market withdrawals. Traditional animal models fail to predict human liver …
trial failures and market withdrawals. Traditional animal models fail to predict human liver …
Fluids alter elasticity measurements: porous wave propagation accounts for shear wave dispersion in elastography
In shear wave elastography, rotational wave speeds are converted to elasticity measures
using elastodynamic theory. The method has a wide range of applications and is the gold …
using elastodynamic theory. The method has a wide range of applications and is the gold …
A critical aspect of bioreactor designing and its application for the generation of tissue engineered construct: Emphasis on clinical translation of bioreactor
Usage of bioreactors in the field of tissue engineering has played a significant role in
enabling a controlled and reproducible change in the formation of damaged tissue on being …
enabling a controlled and reproducible change in the formation of damaged tissue on being …
Current Researches in Modular Biofabrication: Tissue Building Blocks and Bioreactors
Modular tissue engineering (TE) is based on the design, fabrication, and arrangement of
replicated microtissue constructs to generate functional tissues. The advantage of this …
replicated microtissue constructs to generate functional tissues. The advantage of this …
[HTML][HTML] Computational analysis of upscaled fibrotic liver multi-lobule flows and metabolism
The modeling of fibrotic effects on fluid flow and metabolism in the liver can be
computationally challenging. This paper combines innovative concepts based on …
computationally challenging. This paper combines innovative concepts based on …
A multiscale-multiphysics framework for modeling organ-scale liver regrowth
We present a framework for modeling liver regrowth on the organ scale that is based on
three components:(1) a multiscale perfusion model that combines synthetic vascular tree …
three components:(1) a multiscale perfusion model that combines synthetic vascular tree …
Connecting continuum poroelasticity with discrete synthetic vascular trees for modelling liver tissue
The modelling of liver tissue across multiple length scales constitutes a significant
challenge, primarily due to the multiphysics coupling of mechanical response and perfusion …
challenge, primarily due to the multiphysics coupling of mechanical response and perfusion …
Dual continuum upscaling of liver lobule flow and metabolism to the full organ scale
The liver is the body's primary metabolic organ and its functions operate at multiple time and
spatial scales. Here we employ multiscale modelling techniques to describe these functions …
spatial scales. Here we employ multiscale modelling techniques to describe these functions …